Protein Chemical Modification on Endogenous Amino Acids

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Presentation transcript:

Protein Chemical Modification on Endogenous Amino Acids Emmanuel Baslé, Nicolas Joubert, Mathieu Pucheault Chemistry & Biology Volume 17, Issue 3, Pages 213-227 (March 2010) DOI: 10.1016/j.chembiol.2010.02.008 Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 1 Reactivity of Lysine, Arginine, Histidine, Aspartic Acid, Glutamic Acid, and C Termini Chemistry & Biology 2010 17, 213-227DOI: (10.1016/j.chembiol.2010.02.008) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 2 Reactivity of Cysteine and Tyrosine Chemistry & Biology 2010 17, 213-227DOI: (10.1016/j.chembiol.2010.02.008) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 3 Transition Metal-Catalyzed Bioconjugation Chemistry & Biology 2010 17, 213-227DOI: (10.1016/j.chembiol.2010.02.008) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 4 Protein Photolabeling Chemistry & Biology 2010 17, 213-227DOI: (10.1016/j.chembiol.2010.02.008) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 5 Oxidative Coupling and N Terminus Modification Chemistry & Biology 2010 17, 213-227DOI: (10.1016/j.chembiol.2010.02.008) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 6 Main Applications of Protein Covalent Modification Chemistry & Biology 2010 17, 213-227DOI: (10.1016/j.chembiol.2010.02.008) Copyright © 2010 Elsevier Ltd Terms and Conditions

Figure 7 Examples of Trifunctional Probes (A) Binding: arbutin; reaction: benzophenone biradical insertion; detection: purification with biotin (Qvit et al., 2008). (B) Binding: brassinosteroid/BRII; reaction: carbene insertion with diazirine; detection: purification with biotin. (C) Binding: benzensulfonamide/CAII; reaction: histidine epoxide opening; secondary detection by hydrazine-derived ligand/oxime-derived fluorescein exchange (Takaoka et al., 2006). (D) Binding: benzensulfonamide/CAII; reaction: SN2 on tosylate; detection: fluorescence with 7-diethylaminocoumarin (Tsukiji et al., 2009b). Chemistry & Biology 2010 17, 213-227DOI: (10.1016/j.chembiol.2010.02.008) Copyright © 2010 Elsevier Ltd Terms and Conditions