Lipoyl-E2-PDH Gets a Second Job

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Lipoyl-E2-PDH Gets a Second Job Seth W. Dickey, Michael Otto Cell Host & Microbe Volume 22, Issue 5, Pages 581-583 (November 2017) DOI: 10.1016/j.chom.2017.10.018 Copyright © 2017 Terms and Conditions

Figure 1 Dual Roles of S. aureus Lipoyl-E2-PDH Left: in the bacterial cytoplasm, lipoyl-E2-PDH (red) works with the E1 and E3 subunits to form the pyruvate dehydrogenase (PDH) multi-enzyme complex, which links glycolysis to the citric acid cycle by catalyzing the conversion of pyruvate to acetyl-CoA. Right: Grayczyk et al. (2017) discovered that S. aureus secretes lipoyl-E2-PDH where it moonlights outside to block activation of TLR1/2 on macrophages, suppressing the innate immune response to S. aureus infections. Cell Host & Microbe 2017 22, 581-583DOI: (10.1016/j.chom.2017.10.018) Copyright © 2017 Terms and Conditions