How Bad Is the Hedgehog? GLI-Dependent, Hedgehog-Independent Cancers on the Importance of Biomarkers for Proper Patients Selection Delphine Javelaud,

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How Bad Is the Hedgehog? GLI-Dependent, Hedgehog-Independent Cancers on the Importance of Biomarkers for Proper Patients Selection Delphine Javelaud, Aurélien De Reyniès, Alain Mauviel Journal of Investigative Dermatology Symposium Proceedings Volume 19, Issue 2, Pages S87-S88 (December 2018) DOI: 10.1016/j.jisp.2018.09.010 Copyright © 2018 The Authors Terms and Conditions

Figure 1 Crosstalk between TGF-β and HH signaling. TGF-β ligand binding to its receptors activates the SMAD cascade, resulting in transcriptional activation of GLI2. GLI2 protein may either regulate target gene expression downstream of TGF-β signaling or feed into to HH-driven signaling, which occurs via SMO activation within the primary cilium in response to HH binding to its receptor PTCH1. HH, Hedgehog. Journal of Investigative Dermatology Symposium Proceedings 2018 19, S87-S88DOI: (10.1016/j.jisp.2018.09.010) Copyright © 2018 The Authors Terms and Conditions