REVERSAL OF IATROGENIC MYOCARDIAL EDEMA AND RELATED ABNORMALITIES OF DIASTOLIC PROPERTIES IN THE PIG LEFT VENTRICLE David A. Dean, MDa*, Mehrdad M. Amirhamzeh,

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Presentation transcript:

REVERSAL OF IATROGENIC MYOCARDIAL EDEMA AND RELATED ABNORMALITIES OF DIASTOLIC PROPERTIES IN THE PIG LEFT VENTRICLE David A. Dean, MDa*, Mehrdad M. Amirhamzeh, MDa, Chao-Xiang Jia, MDa, Santos E. Cabreriza, MBAa, David G. Rabkin, BAa, Robert Sciacca, EngScD, Marc L. Dickstein, MDc, Henry M. Spotnitz, MDa** The Journal of Thoracic and Cardiovascular Surgery Volume 115, Issue 5, Pages 1209-1214 (May 1998) DOI: 10.1016/S0022-5223(98)70423-4 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Representative pressure-volume data during preload reduction by inferior vena caval occlusion. Raw conductance was converted to absolute volume by means of calibration routines described in the text. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 1209-1214DOI: (10.1016/S0022-5223(98)70423-4) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 Representative LV pressure-volume data after infusion of hemodiluted blood, analyzed by exponential curve fitting. The curves are shifted upward and to the left 3 and 18 minutes after reperfusion. LVM, LV mass by 2-DE. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 1209-1214DOI: (10.1016/S0022-5223(98)70423-4) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Time course of mean LV mass (LVM) calculated by 2-DE and diastolic stiffness constant (β for edema (n = 5) and control groups (n = 6). Statistically significant increases occur in β and LV mass in the edema group at 15 minutes and then return toward normal. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 1209-1214DOI: (10.1016/S0022-5223(98)70423-4) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 4 Time course of heart rate (HR) and end-diastolic volume (EDV) for edema (n = 5) and control groups (n = 6). Heart rate is increased significantly and end-diastolic volume is decreased significantly at the 15-minute time point. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 1209-1214DOI: (10.1016/S0022-5223(98)70423-4) Copyright © 1998 Mosby, Inc. Terms and Conditions