Apoptosis in post-streptococcal glomerulonephritis

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Presentation transcript:

Apoptosis in post-streptococcal glomerulonephritis John Savill, Prof. J. Savill Kidney International Volume 60, Issue 3, Pages 1203-1214 (September 2001) DOI: 10.1046/j.1523-1755.2001.0600031203.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Intraglomerular clearance of apoptotic cells. Electron micrograph of glomerular capillary from rabbit with glomerular injury induced by serum sickness/cyclosporine A7. Note intraluminal macrophage (m) that has ingested several dying cells; one ingested cell (arrow) has classic nuclear condensation of apoptosis (From Professor Guy Neild; magnification ×8000). Kidney International 2001 60, 1203-1214DOI: (10.1046/j.1523-1755.2001.0600031203.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Hypothesis for regulation of macrophage activation by interaction with apoptotic cells. Activated macrophages (Mø) can accelerate leukocyte apoptosis and trigger resident cell apoptosis. Subsequent phagocytosis of the apoptotic progeny deactivates or “reprograms” the macrophage, which then receives signals to promote, repair, and/or emigrate. Mø, macrophages. Kidney International 2001 60, 1203-1214DOI: (10.1046/j.1523-1755.2001.0600031203.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Glomerular endothelial cell apoptosis. Electron micrograph of glomerular capillary from rabbit with glomerular injury induced by serum sickness/cyclosporine A7. On the left (black arrow) an injured glomerular endothelial cell displays typical nuclear morphology of apoptosis. On the right (white arrow) a neutrophil exhibits early apoptotic changes (From Professor Guy Neild; ×2000). Kidney International 2001 60, 1203-1214DOI: (10.1046/j.1523-1755.2001.0600031203.x) Copyright © 2001 International Society of Nephrology Terms and Conditions