Morphological studies in the hippocampus of sut mice (A) Low-power images of the hippocampus from WT and sut mice. Morphological studies in the hippocampus.

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Morphological studies in the hippocampus of sut mice (A) Low-power images of the hippocampus from WT and sut mice. Morphological studies in the hippocampus of sut mice (A) Low-power images of the hippocampus from WT and sut mice. H&E staining revealed no abnormality of gross morphology of the hippocampus. Scale bar, 0.8 mm. (B) Representative electron micrographs showing the asymmetrical synapses in the CA1 stratum radiatum of sut mice and WT controls. Arrowheads indicate individual asymmetrical synapses. Arrows mark the edges of the PSD. Scale bars, 1.5 μm (upper panels) and 0.3 μm (bottom panels). (C) Statistical analyses show no difference in synapse number (WT, 1.18±0.05/μm3; and sut, 1.20±0.17/μm3), the thickness of PSD (WT: 46.1±1.2 nm, n=102 synapses for three mice; and sut: 43.7±9.7nm, n=103 synapses for three mice) and the synaptic cleft (WT: 19.4±0.5 nm, n=102 synapses for three mice; and sut: 4.5±0.5 nm, n=90 synapses for three mice) between WT and sut mice. Yan Li et al. Biosci. Rep. 2012;32:315-321 ©2012 by Portland Press Ltd