Meiotic Microdeletion Breakpoints in the BRCA1 Gene Are Significantly Associated with Symmetric DNA-Sequence Elements Beatrice Schmucker, Michael Krawczak

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Meiotic Microdeletion Breakpoints in the BRCA1 Gene Are Significantly Associated with Symmetric DNA-Sequence Elements Beatrice Schmucker, Michael Krawczak The American Journal of Human Genetics Volume 61, Issue 6, Pages 1454-1456 (December 1997) DOI: 10.1086/301631 Copyright © 1997 The American Society of Human Genetics Terms and Conditions

Figure 1 Partial BRCA1 exon 11 sequence of a 3599/3600del11 carrier and of a control. The deletion junctions are indicated by arrows. Symmetric elements upstream of the proximal breakpoint are boxed. The mutation was detected in a male obligate carrier manifesting prostate cancer and in four first-degree female relatives with breast cancer. The American Journal of Human Genetics 1997 61, 1454-1456DOI: (10.1086/301631) Copyright © 1997 The American Society of Human Genetics Terms and Conditions

Figure 2 Distribution of the minimum distance between a deletion breakpoint and a nearby symmetric element of a given length. Observed (blackened boxes) and expected (shaded boxes) frequencies of distance intervals are shown for element lengths of 5 (A), 6 (B), and 7 (C) nucleotides. The American Journal of Human Genetics 1997 61, 1454-1456DOI: (10.1086/301631) Copyright © 1997 The American Society of Human Genetics Terms and Conditions