IgE in unselected like-sexed monozygotic and dizygotic twins at birth and at 6 to 9 years of age: High but dissimilar genetic influence on IgE levels

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Presentation transcript:

IgE in unselected like-sexed monozygotic and dizygotic twins at birth and at 6 to 9 years of age: High but dissimilar genetic influence on IgE levels Hans Peter Jacobsen, MDa, Anne Maria Herskind, MD, PhDa, Bent Windelborg Nielsen, MD, PhDb, Steffen Husby, MD, PhDa Journal of Allergy and Clinical Immunology Volume 107, Issue 4, Pages 659-663 (April 2001) DOI: 10.1067/mai.2001.113565 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Path model for the influences on serum IgE in twins. The influences are divided into additive factors (A) , genetic dominance factors (D) , and shared (C) and nonshared (E) environmental factors. Additive genetic factors and genetic dominance factors are both perfectly correlated in MZ twins, whereas in DZ twins the correlation between additive genetic factors equals one half and the correlation between genetic dominance factors equals one fourth. Journal of Allergy and Clinical Immunology 2001 107, 659-663DOI: (10.1067/mai.2001.113565) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 Scatter plot on a logarithmic scale of CB IgE versus serum IgE (S-IgE) . Correlation between CB IgE and serum IgE is low (0.04). Journal of Allergy and Clinical Immunology 2001 107, 659-663DOI: (10.1067/mai.2001.113565) Copyright © 2001 Mosby, Inc. Terms and Conditions