Schematic representation of signaling by MCV large T antigen (T-Ag) and small t antigen (t-Ag). Schematic representation of signaling by MCV large T antigen.

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Schematic representation of signaling by MCV large T antigen (T-Ag) and small t antigen (t-Ag). Schematic representation of signaling by MCV large T antigen (T-Ag) and small t antigen (t-Ag). Targets for MCV T-Ag and t-Ag (center column) and biological effects (right column) are shown. ↑, upregulation; ↓, downregulation. pRb, retinoblastoma protein; Vam6p, vacuolar protein-sorting gene product; TLR9, Toll-like receptor 9; 4E-BP1, eukaryotic translation initiation factor 4E-binding protein 1; FBW7, F-box/WD repeat-containing protein 7; NEMO, NF-κB essential modulator. Martyn K. White et al. Clin. Microbiol. Rev. 2014; doi:10.1128/CMR.00124-13