Key mechanistic pathways in DKD

Slides:

Advertisements

Similar presentations

The Virtual Free Radical School Cell Signaling by Oxidants: Mitogen-Activated Protein Kinases (MAPK) and Activator Protein – 1 (AP-1) Brooke T. Mossman*

Advertisements

Does Infection-Induced Immune Activation Contribute to Dementia? Tatiana Barichello 1, 2 ;Jaqueline S. Generoso 2 ;Jessica A. Goularte 2 ;Allan Collodel.

Signal Transduction HLA-DR stimulus specific receptor signal transductiontranscription translation proteins Receptor associating proteins Protein kinease.

Fig. 6. VitabridC12 inhibited cutaneous inflammation via the nuclear factor-κB signaling pathway. Protein extracts were prepared, and western blot analysis.

Copyright © 2002 American Medical Association. All rights reserved.

Lipotoxicity in NASH Journal of Hepatology

Figure 2 Inflammatory pathways affecting hepatic insulin resistance

Figure 2 Cell-mediated disease mechanisms of lupus nephritis

Pathophysiology of the metabolic syndrome

Innate immune-signaling cascades and evidence for upregulation in brain following AIE exposure. Innate immune-signaling cascades and evidence for upregulation.

Bart Staels, PhD The American Journal of Medicine

Figure 2 The unfolded protein response

Figure 4 Simplified T cell and antigen presenting

Prevention of ischemia-reperfusion injury in cardiac surgery: Therapeutic strategies targeting signaling pathways Kay Maeda, MD, PhD, Marc Ruel, MD,

CD9 Is Critical for Cutaneous Wound Healing through JNK Signaling

Toll-like receptors: Applications to dermatologic disease

Lipotoxicity in NASH Journal of Hepatology

Methemoglobinemia: A Diagnosis Not to Be Missed

B-cell Signaling: Protein Kinase Cδ Puts the Brakes on

Toll-like receptor activation: from renal inflammation to fibrosis

Nat. Rev. Cardiol. doi: /nrcardio

Mechanisms of apoptosis and growth arrest by isothiocyanates.

Figure 2 Oestrogen receptor signalling pathways

Nat. Rev. Neurol. doi: /nrneurol

Electromagnetic fields stress living cells

Figure 3 Physiological regulation of autophagy in the heart

Patrick Phelan, MD, Heather E

Schematic view of Trk receptors signalling, showing the three major pathways involved in cell differentiation and survival. Schematic view of Trk receptors.

Mechanisms of rIPC. Mechanisms of rIPC. AP-1, activator protein-1; cGMP, cyclic guanosine monophosphate; CGRP, calcitonin gene-related peptide; COX2, cyclooxygenase.

TCF7L2 ChIP-seq in HCT116 cells.

Chadrick E. Denlinger, MD

Ischemia-reperfusion injury in renal transplantation: 3 key signaling pathways in tubular epithelial cells Stephanie F. Smith, Sarah A. Hosgood, Michael.

The paradox of neuronal insulin action and resistance in the development of aging- associated diseases Sophie M. Steculorum, Maite Solas, Jens C. Brüning

Nat. Rev. Nephrol. doi: /nrneph

Figure 1 NETosis pathways and potential therapeutic targets

Biological network analysis of differentially expressed proteins in both pancreatic cancer and chronic pancreatitis using MetaCore mapping tool. Biological.

Volume 76, Issue 11, Pages (December 2009)

Cis-Urocanic Acid Enhances Prostaglandin E2 Release and Apoptotic Cell Death via Reactive Oxygen Species in Human Keratinocytes Kazuyo Kaneko, Susan.

Volume 73, Issue 1, Pages 5-7 (January 2008)

GDF11 and the Mythical Fountain of Youth

Juliana Saraiva Anjos, MD, Ludmila F. M. F

Volume 94, Issue 6, Pages (December 2018)

Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart

Clusters from the functional network

Inflammatory stimuli increase angiopoietin-like protein 4 (ANGPTL4) gene and protein expression in human macrophages. Inflammatory stimuli increase angiopoietin-like.

Schematic representation of seven relevant Gln-modulated protein interactions in the HCT-8 human epithelial cell line under CH11 experimental apoptotic.

Volume 95, Issue 4, Pages (April 2019)

Volume 54, Pages S189-S191 (September 1998)

Targets of thiazolidinedione (TZD) drugs in Alzheimer’s disease.

Platelet-derived growth factor (PDGF) signalling pathway.

Figure 1 Altered modes of cAMP signalling at PTHR1

The RAS-MEK-ERK pathway represents a chain of protein signalling pathway that responds to a mitogen binding to a cell surface receptor. The RAS-MEK-ERK.

Fig. 8. Involvement of BDNF/TrkB and ERK/CREB axes in nitroglycerin-induced rat migraine and effects of estrogen on these signals in the migraine. Involvement.

Effects of streptozotocin treatment on several kinases that can phosphorylate tau. Effects of streptozotocin treatment on several kinases that can phosphorylate.

Gene set enrichment analysis reveals MafA regulation of many key β-cell activities. Gene set enrichment analysis reveals MafA regulation of many key β-cell.

Volume 85, Issue 3, Pages (March 2014)

The mitogen-activated protein kinase (MAPK) pathway showing mutations identified in pulmonary Langerhans cell histiocytosis (PLCH). The mitogen-activated.

Proposed pathway for regulated ATP release from human erythrocytes

CML-HSA treatment activates MAPK family members ERK1/2 and p38 but not JNK. Samples were taken at the indicated times after 100 μg/ml CML-HSA exposure.

Stanley Nattel JACEP 2017;3:

Plots showing the difference in expression rate versus the difference in averaged transcript amount between patients with SLE with SLEDAI ≥10 and those.

Figure 5 TLR-dependent signaling pathways inhibited by glatiramer acetate Myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-1 receptor.

Yiannis S. Chatzizisis et al. JACC 2007;49:

EMT alters activation of AKT and serum-independent proliferation.

Hippo-based model. Hippo-based model. Arrows point out the direction of signaling: in orange, the YAP signaling effects on p73 driven by c-Abl, in blue.

Schematic representation of signaling pathways associated with cannabinoid receptor activation induced by its agonists. Schematic representation of signaling.

Different signaling pathways of TLR2, Nod, and TNFR1 in response to ligand, resulting in activation of NF-κB, the nuclear transcriptional factor responsible.

Airway smooth muscle: A modulator of airway remodeling in asthma

Mechanisms leading to liver steatosis.

Toll-like receptors, adapter proteins, and signaling molecules.

Presentation transcript:

Key mechanistic pathways in DKD Key mechanistic pathways in DKD. CD36, cluster of differentiation 36; CLA-1, LIMPII analogous-1; ERK, extracellular signal-regulated kinase; GBM, glomerular basement membrane thickening; JNK, c-Jun N-terminal kinase; NADPH, nicotinamide adenine dinucleotide phosphate; Nrf2, nuclear factor (erythroid-derived 2)-like 2; SAA, serum amyloid A; SBP-1, selenium-binding protein 1; TLR2, toll-like receptor 2; TLR4, toll-like receptor 4. Key mechanistic pathways in DKD. CD36, cluster of differentiation 36; CLA-1, LIMPII analogous-1; ERK, extracellular signal-regulated kinase; GBM, glomerular basement membrane thickening; JNK, c-Jun N-terminal kinase; NADPH, nicotinamide adenine dinucleotide phosphate; Nrf2, nuclear factor (erythroid-derived 2)-like 2; SAA, serum amyloid A; SBP-1, selenium-binding protein 1; TLR2, toll-like receptor 2; TLR4, toll-like receptor 4. Brad P. Dieter et al. Diabetes Spectr 2015;28:167-174 ©2015 by American Diabetes Association