Volume 114, Issue 4, Pages (April 1998)

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Volume 114, Issue 4, Pages 633-639 (April 1998) Inflammation and intestinal metaplasia of the gastric cardia: The role of gastroesophageal reflux and H. pylori infection John R. Goldblum*, Joseph J. Vicari‡, Gary W. Falk‡, Thomas W. Rice§, Richard M. Peek∥, Kirk Easley¶, Joel E. Richter‡ Gastroenterology Volume 114, Issue 4, Pages 633-639 (April 1998) DOI: 10.1016/S0016-5085(98)70576-1 Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 (A) Normal gastric cardia. The cardia mucosa shows relatively tightly packed mucus-secreting glands, and the lamina propria is devoid of any significant inflammation (H&E stain). (B) Carditis. There is significant expansion of the lamina propria predominantly by lymphocytes and plasma cells, spreading apart the mucus-secreting glands of the cardia (H&E; original magnification 20×). Gastroenterology 1998 114, 633-639DOI: (10.1016/S0016-5085(98)70576-1) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 1 (A) Normal gastric cardia. The cardia mucosa shows relatively tightly packed mucus-secreting glands, and the lamina propria is devoid of any significant inflammation (H&E stain). (B) Carditis. There is significant expansion of the lamina propria predominantly by lymphocytes and plasma cells, spreading apart the mucus-secreting glands of the cardia (H&E; original magnification 20×). Gastroenterology 1998 114, 633-639DOI: (10.1016/S0016-5085(98)70576-1) Copyright © 1998 American Gastroenterological Association Terms and Conditions

Fig. 2 Intestinal metaplasia of the cardia in a background of carditis. There is focal replacement of the gastric glands by intestinal metaplasia, characterized by the presence of goblet cells (arrow). The surrounding lamina propria is expanded predominantly by lymphocytes and plasma cells, indicative of carditis (H&E; original magnification 20×). Gastroenterology 1998 114, 633-639DOI: (10.1016/S0016-5085(98)70576-1) Copyright © 1998 American Gastroenterological Association Terms and Conditions