P53 and Prognosis Cell Volume 120, Issue 1, Pages 7-10 (January 2005) Karen H. Vousden, Carol Prives  Cell  Volume 120, Issue 1, Pages 7-10 (January 2005) DOI: 10.1016/j.cell.2004.12.027

Figure 1 More Than One Way to Block p53 While loss of p53 activity appears to be essential for malignant progression, there are several routes through which this can be achieved. Each of these different mechanisms blocks p53 activity, but their downstream effects may be profoundly different. Examples shown here are the expression of mutant forms of p53 or expression of excess Mdm2. Both may inhibit the regulation of target genes involved in tumor suppression by either p53 or p53 homologs p63 and p73. However, mutant p53 and Mdm2 each have additional unique targets, and perturbations in these may result in important differences in the phenotype of the resulting tumor. Cell 2005 120, 7-10DOI: (10.1016/j.cell.2004.12.027)