Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans Heather J. Chial, Michael Camilleri, Irene Ferber,

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Presentation transcript:

Effects of venlafaxine, buspirone, and placebo on colonic sensorimotor functions in healthy humans Heather J. Chial, Michael Camilleri, Irene Ferber, Silvia Delgado-Aros, Duane Burton, Sanna McKinzie, Alan R. Zinsmeister Clinical Gastroenterology and Hepatology Volume 1, Issue 3, Pages 211-218 (May 2003) DOI: 10.1016/S1542-3565(03)70038-X Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 1 Experimental protocol. Outline of the experimental protocol. ■, Assessment of colonic compliance, fasting tone, and sensation; ▩, assessment of postprandial colonic tone. Clinical Gastroenterology and Hepatology 2003 1, 211-218DOI: (10.1016/S1542-3565(03)70038-X) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 2 Compliance curves (adjusted) showing median data. Note venlafaxine increases colonic compliance. Clinical Gastroenterology and Hepatology 2003 1, 211-218DOI: (10.1016/S1542-3565(03)70038-X) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 3 Effects on fasting colonic tone. Note the significant increase in intracolonic balloon volume after drug administration for venlafaxine, suggesting it relaxes the colon. *Overall P < 0.01; P = 0.003 for venlafaxine vs. placebo, unadjusted for 3 pairwise comparisons. Clinical Gastroenterology and Hepatology 2003 1, 211-218DOI: (10.1016/S1542-3565(03)70038-X) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 4 Effects on postprandial colonic tone. *Overall P < 0.01; P = 0.003 for venlafaxine vs. placebo, unadjusted for 3 pairwise comparisons. Clinical Gastroenterology and Hepatology 2003 1, 211-218DOI: (10.1016/S1542-3565(03)70038-X) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 5 Effects on (A) first sensation and (B) first perception of gas. Overall P = 0.1 for first sensation. Overall P = 0.07 for first perception of gas. Clinical Gastroenterology and Hepatology 2003 1, 211-218DOI: (10.1016/S1542-3565(03)70038-X) Copyright © 2003 American Gastroenterological Association Terms and Conditions

Fig. 6 Overall effect on sensation scores for pain in response to increasing pressures. *Overall P = 0.02 for the linear trend over the 4 pressure levels. Clinical Gastroenterology and Hepatology 2003 1, 211-218DOI: (10.1016/S1542-3565(03)70038-X) Copyright © 2003 American Gastroenterological Association Terms and Conditions