Impact of the Evolution of the Fontan Operation on Early and Late Mortality: A Single- Center Experience of 405 Patients Over 3 Decades Hideo Ohuchi,

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Impact of the Evolution of the Fontan Operation on Early and Late Mortality: A Single- Center Experience of 405 Patients Over 3 Decades Hideo Ohuchi, MD, PhD, Koji Kagisaki, MD, Aya Miyazaki, MD, Masataka Kitano, MD, Satoshi Yazaki, MD, Heima Sakaguchi, MD, PhD, Hajime Ichikawa, MD, PhD, Osamu Yamada, MD, Toshikatsu Yagihara, MD, PhD The Annals of Thoracic Surgery Volume 92, Issue 4, Pages 1457-1466 (October 2011) DOI: 10.1016/j.athoracsur.2011.05.055 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 (a) The Kaplan-Meier survival-rate curves for all types of Fontan operations (ie, atriopulmonary connection [APC], intra-atrial rerouting [IAR], and extracardiac rerouting [ECR]. (b) Curves for patients with and without heterotaxy syndrome. (c) Curves for patients who required atrioventricular valve repair (AVVR) at the time of the Fontan operation. (d) Curves for late survivors (6 or more months after Fontan operation) in patients with atriopulmonary connection, intra-atrial rerouting, and extracardiac rerouting. The vertical bars represent 95% confidence intervals. The Annals of Thoracic Surgery 2011 92, 1457-1466DOI: (10.1016/j.athoracsur.2011.05.055) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Effect of (a) repair of a total anomalous pulmonary vein connection (TAPVC) and (b) atrioventricular valve repair (AVVR) at the time of the Fontan operation, and (c) of a low ejection fraction (EF) of the systemic ventricle inpatients with a Fontan operation with. The patients with a Fontan operation done with extracardiac rerouting (ECR) (c) were divided into two groups according to the median value (0.57) of their ejection fraction. The vertical bars represent 95% confidence intervals. The Annals of Thoracic Surgery 2011 92, 1457-1466DOI: (10.1016/j.athoracsur.2011.05.055) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Effect of heterotaxy syndrome on the overall survival rate in patients with Fontan operations with (a) atriopulmonary connection (APC), (b) intra-atrial rerouting (IAR), and (c) extracardiac rerouting (ECR). The vertical bars represent 95% confidence intervals. The Annals of Thoracic Surgery 2011 92, 1457-1466DOI: (10.1016/j.athoracsur.2011.05.055) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions