Julia Humphries, MSc, Catharine L

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Presentation transcript:

Monocyte chemotactic protein-1 (MCP-1) accelerates the organization and resolution of venous thrombi Julia Humphries, MSc, Catharine L. McGuinness, FRCS, Alberto Smith, PhD, Matthew Waltham, MA, FRCS, Robin Poston, MD, FRCPath, Kevin G. Burnand, MS, FRCS Journal of Vascular Surgery Volume 30, Issue 5, Pages 894-900 (November 1999) DOI: 10.1016/S0741-5214(99)70014-5 Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Monocyte chemotactic protein-1 (MCP-1) content of normal arteries and veins, vein walls adjacent to naturally resolving thrombi at day 1 and day 7, and vein wall combined with thrombi at day 14 (numbers refer to medians). Journal of Vascular Surgery 1999 30, 894-900DOI: (10.1016/S0741-5214(99)70014-5) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Monocyte chemotactic protein-1 (MCP-1) content of naturally resolving thrombi at day 1 and day 7 (numbers refer to medians). Journal of Vascular Surgery 1999 30, 894-900DOI: (10.1016/S0741-5214(99)70014-5) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Photomicrographs of representative sections taken from monocyte chemotactic protein-1 (MCP-1)–treated and control thrombi stained with Martius scarlet blue (original magnification, 25×; arrows point to organized thrombus). Journal of Vascular Surgery 1999 30, 894-900DOI: (10.1016/S0741-5214(99)70014-5) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Organization scores for monocyte chemotactic protein-1 (MCP-1)–treated and control thrombi, according to computer-image analysis and blinded-observer analysis (n = 5; numbers refer to medians). Journal of Vascular Surgery 1999 30, 894-900DOI: (10.1016/S0741-5214(99)70014-5) Copyright © 1999 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions