The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse S.S. Glasson, M.G. Chambers, W.B. Van.

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The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the mouse S.S. Glasson, M.G. Chambers, W.B. Van Den Berg, C.B. Little Osteoarthritis and Cartilage Volume 18, Pages S17-S23 (October 2010) DOI: 10.1016/j.joca.2010.05.025 Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Safranin-O photomicrographs showing the MFC (above) and MTP (below) and the medial meniscus (left), displaying a variety of OA severity and semi-quantitative scores. First score represents MFC, second score is MTP; (A) 0, 0.5; (B) 0, 1; (C) 0.5, 2; (D) 3, 3; (E) 0, 4; (F) 5, 6. Osteoarthritis and Cartilage 2010 18, S17-S23DOI: (10.1016/j.joca.2010.05.025) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Variation across experienced and novice scorers for maximal histologic score across the MTP (A), MFC (B), and summed MTP (C) and MFC (D) scores. The greatest consistency in scores was observed for the summed MTP data sets. Osteoarthritis and Cartilage 2010 18, S17-S23DOI: (10.1016/j.joca.2010.05.025) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Intra-observer reproducibility over time was evaluated by comparing the scores for the same images at two different times at a minimum of 1 week apart. Both the MTP (A) and MFC (B) data sets, each with 40 paired scores, had a high correlation. The highest reproducibility was observed with the MTP lesions. The dotted lines indicate the 95% confidence intervals. Osteoarthritis and Cartilage 2010 18, S17-S23DOI: (10.1016/j.joca.2010.05.025) Copyright © 2010 Osteoarthritis Research Society International Terms and Conditions