David C. Stuesse, MDa, George D. Giraud, MD, PhDb, Angelo A

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Presentation transcript:

Hemodynamic effects of S-nitrosocysteine, an intravenous regional vasodilator David C. Stuesse, MDa, George D. Giraud, MD, PhDb, Angelo A. Vlessis, MD, PhDa, b, c, Albert Starr, MDd, Donald D. Trunkey, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 122, Issue 2, Pages 371-377 (August 2001) DOI: 10.1067/mtc.2001.115699 Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Effect of intravenous S-nitrosocysteine infusion on mean systemic arterial pressure. Values represent mean ± SD. Asterisks represent a significant change in pressure compared with baseline values (P <.05). The Journal of Thoracic and Cardiovascular Surgery 2001 122, 371-377DOI: (10.1067/mtc.2001.115699) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Effect of intravenous S-nitrosocysteine infusion on mean pulmonary arterial pressure. Each symbol represents mean ± SD. Asterisks represent a significant change in pressure compared with baseline values (P <.05). The Journal of Thoracic and Cardiovascular Surgery 2001 122, 371-377DOI: (10.1067/mtc.2001.115699) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Effect of intravenous S-nitrosocysteine infusion on regional blood flows. Values are percentage changes from baseline for the superior mesenteric (SMA) , renal, iliac, and coronary arteries. Each symbol represents the mean change in flow. Asterisks represent a significant change in flow compared with baseline values (P <.05). The Journal of Thoracic and Cardiovascular Surgery 2001 122, 371-377DOI: (10.1067/mtc.2001.115699) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Effect of intravenous S-nitrosocysteine infusion on the systemic PaO2. Each symbol represents mean ± SD. Asterisks represent a significant change in partial pressure compared with baseline values (P <.05). The Journal of Thoracic and Cardiovascular Surgery 2001 122, 371-377DOI: (10.1067/mtc.2001.115699) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Relationship between S-nitrosocysteine intravenous infusion and nitrosothiol concentration in plasma from arterial blood. Values represent mean ± SD. The Journal of Thoracic and Cardiovascular Surgery 2001 122, 371-377DOI: (10.1067/mtc.2001.115699) Copyright © 2001 American Association for Thoracic Surgery Terms and Conditions