Viperin; A novel chondrogenic regulator

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Viperin; A novel chondrogenic regulator M.M. Steinbusch, M.M. Caron, F. Eckmann, E. Lausch, L.W. van Rhijn, B. Zabel, T.J. Welting Osteoarthritis and Cartilage Volume 23, Pages A148-A149 (April 2015) DOI: 10.1016/j.joca.2015.02.895 Copyright © 2015 Terms and Conditions

Figure 1. A) KD of viperin expression by RNAi results in a 90% reduction of Col2a1 gene expression at day 7 in ATDC5 chondrogenic differentiation. Expression of the hypertrophic markers Col10a1 and Mef2c was not affected; skewing cells towards hypertrophy. KD of viperin also results in increased ER stress indicated by increased expression of Chop. B) Moreover, viperin KD resulted in 32% reduced protein secretion (ATDC5 d4). Osteoarthritis and Cartilage 2015 23, A148-A149DOI: (10.1016/j.joca.2015.02.895) Copyright © 2015 Terms and Conditions