Tummy Time: The Infant Microbiota–IgA Connection Tyler A. Rice, Noah W. Palm  Cell Host & Microbe  Volume 20, Issue 1, Pages 6-8 (July 2016) DOI: 10.1016/j.chom.2016.06.014 Copyright © 2016 Terms and Conditions

Figure 1 Maturation of the Gut Microbiota and Immune Response from Birth into Childhood The studies of Planer et al. (2016) reveal the patterns of maturation of the gut microbiota and the immune response to the microbiota in healthy humans from birth to age 3. During this period, the major source of IgA in breast-fed babies transitions from passively acquired, maternal IgA in breast milk to infant, host-derived IgA; this change naturally also coincides with the transition to solid foods. While the dramatic change in diet during this transition clearly contributes to maturation of the microbiota, Planer et al. (2016) also find that intrinsic features of specific bacterial taxa often dictate the IgA responses that are observed. Cell Host & Microbe 2016 20, 6-8DOI: (10.1016/j.chom.2016.06.014) Copyright © 2016 Terms and Conditions