Tissue regeneration observed in a porous acellular bovine pericardium used to repair a myocardial defect in the right ventricle of a rat model Yen Chang,

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Presentation transcript:

Tissue regeneration observed in a porous acellular bovine pericardium used to repair a myocardial defect in the right ventricle of a rat model Yen Chang, MD, Sung-Ching Chen, MS, Hao-Ji Wei, MD, Tsu-Juey Wu, MD, PhD, Huang-Chien Liang, PhD, Po-Hong Lai, MS, Hang- Hsing Yang, BS, Hsing-Wen Sung, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 130, Issue 3, Pages 705.e1-705.e10 (September 2005) DOI: 10.1016/j.jtcvs.2005.04.007 Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Local electrograms obtained from the electrodes located on the epicardial surfaces of the e-PTFE and AGP patches and their adjacent rat native myocardia immediately after implantation and those observed at 4 and 12 weeks postoperatively. a and b, e-PTFE immediately after implantation; c and d, e-PTFE at 4 weeks postoperatively; e and f, e-PTFE at 12 weeks postoperatively; g and h, AGP immediately after implantation; i and j, AGP at 4 weeks postoperatively; k and l, AGP at 12 weeks postoperatively. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 705.e1-705.e10DOI: (10.1016/j.jtcvs.2005.04.007) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Photomicrographs of the e-PTFE and AGP patches stained with an antibody against factor VIII (a and b: original magnification, 800×), van Gieson (c and d: original magnification, 800×), and a monoclonal antibody against α-SMA (e and f: original magnification, 400×) retrieved at 4 weeks postoperatively. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 705.e1-705.e10DOI: (10.1016/j.jtcvs.2005.04.007) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Photomicrographs of the middle layers of the e-PTFE and AGP patches stained with H&E (a and b), Masson trichrome (c and d), and a monoclonal antibody against α-SMA (e and f) retrieved at 12 weeks postoperatively. (Original magnification, 400×.) The Journal of Thoracic and Cardiovascular Surgery 2005 130, 705.e1-705.e10DOI: (10.1016/j.jtcvs.2005.04.007) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure E1 Photomicrographs of the bovine pericardium before cell extraction (a) and the prepared AGP patch (b), with the acellular bovine pericardium additionally treated with acetic acid, subsequently treated with collagenase, and stained with H&E (original magnification, 200×), and scanning electron microscopic micrographs of the acellular bovine pericardium treated with acetic acid (c) and further treated with collagenase (d; the AGP patch). The Journal of Thoracic and Cardiovascular Surgery 2005 130, 705.e1-705.e10DOI: (10.1016/j.jtcvs.2005.04.007) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure E2 Photomicrographs of the inner (endocardial) layers of the e-PTFE patch (a) and the AGP patch (b) and the outer (epicardial) layers of the e-PTFE patch (c) and the AGP patch (d) stained with H&E retrieved at 4 weeks postoperatively. (Original magnification 200×.) The Journal of Thoracic and Cardiovascular Surgery 2005 130, 705.e1-705.e10DOI: (10.1016/j.jtcvs.2005.04.007) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions

Figure E3 Photomicrographs of the middle layers of the e-PTFE and AGP patches stained with H&E (a and b: original magnification 400×), Masson trichrome (c and d: original magnification 400×), EVG (e and f: original magnification 400×), and safranin-O (g and h: original magnification 200×) retrieved at 4 weeks postoperatively. The Journal of Thoracic and Cardiovascular Surgery 2005 130, 705.e1-705.e10DOI: (10.1016/j.jtcvs.2005.04.007) Copyright © 2005 The American Association for Thoracic Surgery Terms and Conditions