Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate.

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Alterations in subchondral bone plate, trabecular bone and articular cartilage properties of rabbit femoral condyles at 4 weeks after anterior cruciate ligament transection C. Florea, M.K.H. Malo, J. Rautiainen, J.T.A. Mäkelä, J.M. Fick, M.T. Nieminen, J.S. Jurvelin, A. Davidescu, R.K. Korhonen Osteoarthritis and Cartilage Volume 23, Issue 3, Pages 414-422 (March 2015) DOI: 10.1016/j.joca.2014.11.023 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 (A) 3D reconstruction of femoral condyles with VOIs indicated. (B) 3D reconstruction of medial VOI. (C) Subchondral bone plate VOI. (D) Trabecular bone VOI. (E) The VOIs were placed in the weight-bearing regions of femoral condyles. Coronal microCT slices of rabbit medial and lateral femoral condyles in experimental (ACLT) and CTRL groups. Osteoarthritis and Cartilage 2015 23, 414-422DOI: (10.1016/j.joca.2014.11.023) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Medial and lateral rabbit femoral condyles. Dashed vertical lines represent the cutting direction line taken for FTIR, PLM and DD measurements. The biomechanical testing was conducted on the weight-bearing regions of femoral condyles (superimposed solid circles). FTIR, PLM and DD were conducted for the tissue at the same locations. Osteoarthritis and Cartilage 2015 23, 414-422DOI: (10.1016/j.joca.2014.11.023) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Representative histologic rabbit cartilage sections of medial and lateral femoral condyles labeled with Safranin-O in experimental (ACLT) and CTRL groups. Original magnification, 4×. Osteoarthritis and Cartilage 2015 23, 414-422DOI: (10.1016/j.joca.2014.11.023) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Collagen content (AU = absorption unit), collagen orientation angle and PG content of cartilage in ACLT (blue line) and CTRL (red line) groups as a function of tissue depth (mean, 95% CI, n = 8 in both groups), measured with FTIR, PLM and DD, respectively. (A) Medial femoral condyle compartment; (B) lateral femoral condyle compartment. The solid, horizontal line above indicates where significant differences occurred (P < 0.05). Osteoarthritis and Cartilage 2015 23, 414-422DOI: (10.1016/j.joca.2014.11.023) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions