Figure 1 Phenotype and functional properties of B cells in MS and HCs at baseline Phenotype and functional properties of B cells in MS and HCs at baseline.

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Figure 1 Phenotype and functional properties of B cells in MS and HCs at baseline Phenotype and functional properties of B cells in MS and HCs at baseline (A) Comparison of B-cell subset distribution in MS patient groups and HCs. Comparison of percentages of transitional, mature naive, marginal zone, switched memory, IgM-only, IgD-only B cells, exhausted B cells, and plasmablasts. (B) Comparison of functional properties of B cells in MS patient groups and HCs. Comparison of percentages of IL-6– and IL-10–producing B cells and IL-6/IL-10–producing B-cell ratio. CIS = clinically isolated syndrome; HC = healthy control; IL = interleukin; RIS = radiologically isolated syndrome; RRMS = relapsing remitting MS. Thomas Guerrier et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e431 Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.