Slow Decline in Allograft Function in a Renal Transplant Patient Heidi M. Schaefer, MD, J. Harold Helderman, MD, Agnes B. Fogo, MD  American Journal of Kidney Diseases  Volume 48, Issue 2, Pages 335-338 (August 2006) DOI: 10.1053/j.ajkd.2006.02.193 Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 1 Low-power view of the transplant biopsy specimen shows extensive tubulointerstitial atrophy and fibrosis, but no polarizable material was identified in this paraformaldehyde-fixed and processed material (Jones silver stain; original magnification ×100). American Journal of Kidney Diseases 2006 48, 335-338DOI: (10.1053/j.ajkd.2006.02.193) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 2 Frozen section shows numerous crystals in tubules (hematoxylin and eosin; original magnification ×200). American Journal of Kidney Diseases 2006 48, 335-338DOI: (10.1053/j.ajkd.2006.02.193) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 3 Polarized examination of frozen tissue shows abundant intratubular crystals (polarized hematoxylin and eosin; original magnification ×100). American Journal of Kidney Diseases 2006 48, 335-338DOI: (10.1053/j.ajkd.2006.02.193) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions

Fig 4 Characteristic rhomboid and rectangular to ovoid spaces representing spaces left by dissolved cystine crystals are present by electron microscopy in tubular cells and also were seen in the interstitium (electron microscopy; original magnification ×11,000). American Journal of Kidney Diseases 2006 48, 335-338DOI: (10.1053/j.ajkd.2006.02.193) Copyright © 2006 National Kidney Foundation, Inc. Terms and Conditions