Is parental consanguinity associated with reduced ovarian reserve?

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Presentation transcript:

Is parental consanguinity associated with reduced ovarian reserve? Tanja Seher, Elisabeth Thiering, Majdah al Azemi, Joachim Heinrich, Carsten B. Schmidt-Weber, Coleen Kivlahan, Jan Gutermuth, Human M. Fatemi Reproductive BioMedicine Online Volume 31, Issue 3, Pages 427-433 (September 2015) DOI: 10.1016/j.rbmo.2015.06.003 Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Significantly lower antral follicle count (AFC) in female offspring of consanguineous parents. Transvaginal ultrasound reveals significantly lower AFC (median = 7) in women descending from consanguineous marriages in comparison to women from non-consanguineous marriages (median = 11) (***P < 0.0001). Reproductive BioMedicine Online 2015 31, 427-433DOI: (10.1016/j.rbmo.2015.06.003) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Premenopausal antral follicle count (AFC) and anti-Müllerian hormone in young females descending from consanguineous unions. Physiological age-dependent decline of AFC in non-consanguineous patients, while consanguineous patients revealed AFC-concentrations that indicate low ovarian reserve at all ages examined (20–39 years). Reproductive BioMedicine Online 2015 31, 427-433DOI: (10.1016/j.rbmo.2015.06.003) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions