BRAFV600E and NRASQ61R Homogeneity in Melanoma Tumors Arnaud Uguen, Matthieu Talagas, Pascale Marcorelles, Marc De Braekeleer  Journal of Investigative Dermatology  Volume 136, Issue 1, Pages 337-338 (January 2016) DOI: 10.1038/JID.2015.348 Copyright © 2015 The Authors Terms and Conditions

Figure 1 Example of anti-NRASQ61R immunohistochemistry (clone SP174) in an NRASQ61R mutated melanoma. Different intensities of staining are seen at (a) low (scale bar = 5 mm) and high magnification with progression of the signal from (b) weak (scale bar = 0.1 mm), (c) moderate (scale bar = 0.1 mm) to (d) strong (scale bar = 0.1 mm) staining of tumor cells, supporting technical issues more than true biological heterogeneity. Journal of Investigative Dermatology 2016 136, 337-338DOI: (10.1038/JID.2015.348) Copyright © 2015 The Authors Terms and Conditions