Metalloproteinase expression in venous aneurysms

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Presentation transcript:

Metalloproteinase expression in venous aneurysms Chance Irwin, MD, Alan Synn, MD, Larry Kraiss, MD, Qixu Zhang, MD, PhD, Moya M. Griffen, MD, Glenn C. Hunter, MD Journal of Vascular Surgery Volume 48, Issue 5, Pages 1278-1285 (November 2008) DOI: 10.1016/j.jvs.2008.06.056 Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 1 Color flow duplex ultrasound image of a typical popliteal venous aneurysm in (A) longitudinal and (B) transverse views. Journal of Vascular Surgery 2008 48, 1278-1285DOI: (10.1016/j.jvs.2008.06.056) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 2 Phlebography showing lobulated (A) and saccular (B) popliteal venous aneurysms. Journal of Vascular Surgery 2008 48, 1278-1285DOI: (10.1016/j.jvs.2008.06.056) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 3 Operative photograph shows the (A) venous aneurysm (VA) exposed, (B) thrombus in the lumen, and (C) completion of the repair. Journal of Vascular Surgery 2008 48, 1278-1285DOI: (10.1016/j.jvs.2008.06.056) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 4 A venous aneurysm of the hand is shown. Journal of Vascular Surgery 2008 48, 1278-1285DOI: (10.1016/j.jvs.2008.06.056) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 5 Histology and immunohistochemistry comparing representative sections of normal vein, varicose vein, and venous aneurysm (original magnification ×200) demonstrating attenuation of the venous wall in varicose vein and venous aneurysm. The expression of matrix metalloproteinase (MMP) -2, -9, and -13 is increased in venous aneurysms compared with normal vein and varicose vein. H&E, Hematoxylin and eosin. Journal of Vascular Surgery 2008 48, 1278-1285DOI: (10.1016/j.jvs.2008.06.056) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 6 Western immunoblot demonstrating variable expression of matrix metalloproteinase (MMP) -2, MMP-9, and tissue inhibitor of metalloproteinase (TIMP)-2 in varicose vein (VV), normal saphenous vein (NSV), and venous aneurysm (VA). One specimen in each group demonstrated increased expression of TIMP-2. Journal of Vascular Surgery 2008 48, 1278-1285DOI: (10.1016/j.jvs.2008.06.056) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions

Fig 7 Gelatin zymography showing expression of pro-matrix metalloproteinase (MMP)-2 and pro-MMP-9. Pro-MMP-2 was detected in all specimens with variable activity. NSV, Normal saphenous vein; VA, venous aneurysm; VV, varicose vein. Journal of Vascular Surgery 2008 48, 1278-1285DOI: (10.1016/j.jvs.2008.06.056) Copyright © 2008 The Society for Vascular Surgery Terms and Conditions