Costimulatory molecules in the developing human gastrointestinal tract: A pathway for fetal allergen priming Catherine A. Jones, PhD, Gillian H.S. Vance,

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Presentation transcript:

Costimulatory molecules in the developing human gastrointestinal tract: A pathway for fetal allergen priming Catherine A. Jones, PhD, Gillian H.S. Vance, MRCP, Lynsey L. Power, Sylvia L.F. Pender, PhD, Thomas T. MacDonald, MRCPath, PhD, John O. Warner, MD Journal of Allergy and Clinical Immunology Volume 108, Issue 2, Pages 235-241 (August 2001) DOI: 10.1067/mai.2001.117178 Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 1 Antigen-presenting cell markers and costimulatory molecules within human fetal gut. Immunohistochemistry was used to evaluate the expression of MHC class II (a ), CD14 (b ), CD68 (c ), CD20 (d ), CD83 (e ), CD40 (f ), and CD86 (g ). An isotype-matched control was always included (h ). Representative examples of a total of 25 different tissues are shown. Scale bar = 0.2 mm. Journal of Allergy and Clinical Immunology 2001 108, 235-241DOI: (10.1067/mai.2001.117178) Copyright © 2001 Mosby, Inc. Terms and Conditions

Fig. 2 T lymphocytes and costimulatory counterligands within human fetal gut. Immunohistochemistry was used to evaluate the expression of CD3 (a ), CD28 (b ), CD40L (c ), and CTLA-4 (d ). An isotype control was always included (e ). Representative examples of a total of 25 different tissues are shown. Scale bar = 0.2 mm. Journal of Allergy and Clinical Immunology 2001 108, 235-241DOI: (10.1067/mai.2001.117178) Copyright © 2001 Mosby, Inc. Terms and Conditions