Jennifer S. Kim, MD, Anna Nowak-Węgrzyn, MD, Scott H

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Presentation transcript:

Dietary baked milk accelerates the resolution of cow’s milk allergy in children Jennifer S. Kim, MD, Anna Nowak-Węgrzyn, MD, Scott H. Sicherer, MD, Sally Noone, RN, Erin L. Moshier, MS, Hugh A. Sampson, MD Journal of Allergy and Clinical Immunology Volume 128, Issue 1, Pages 125-131.e2 (July 2011) DOI: 10.1016/j.jaci.2011.04.036 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flow diagram of study participants. Journal of Allergy and Clinical Immunology 2011 128, 125-131.e2DOI: (10.1016/j.jaci.2011.04.036) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Development of tolerance: per-protocol (PP) versus comparison groups. The log-rank P value comparing survival between the per-protocol versus comparison groups is less than .001. Subjects in the per-protocol group were 3.6 times more likely to have unheated milk tolerance than subjects in the comparison group over the follow-up period (hazard ratio, 3.57; 95% CI, 1.78-7.16; P < .001) adjusted for sex, age at initial visit, and baseline milk-specific IgE levels. We present data up to 60 months because beyond 60 months, the CIs were very wide as a result of the large number of censored data. Journal of Allergy and Clinical Immunology 2011 128, 125-131.e2DOI: (10.1016/j.jaci.2011.04.036) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Development of tolerance in the active group stratified by initial baked milk challenge: tolerant versus reactive. The log-rank P value comparing time to development of tolerance between the initially baked milk–tolerant versus initially baked milk–reactive groups is less than .001. Subjects who were initially baked milk tolerant are 7.6 times more likely to have unheated milk tolerance than subjects who were initially baked milk reactive over the follow-up period (hazard ratio, 7.62; 95% CI, 1.75-33.14; P = .007) adjusted for sex, age at initial visit, and baseline milk-specific IgE levels. We present data up to 60 months because beyond 60 months, the CIs were very wide as a result of the large number of censored data. Journal of Allergy and Clinical Immunology 2011 128, 125-131.e2DOI: (10.1016/j.jaci.2011.04.036) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions