Volume 140, Issue 1, Pages 124-131 (January 2011) Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study  Christopher D. Williams, Joel Stengel, Michael I. Asike, Dawn M. Torres, Janet Shaw, Maricela Contreras, Cristy L. Landt, Stephen A. Harrison  Gastroenterology  Volume 140, Issue 1, Pages 124-131 (January 2011) DOI: 10.1053/j.gastro.2010.09.038 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Patient flowchart. Gastroenterology 2011 140, 124-131DOI: (10.1053/j.gastro.2010.09.038) Copyright © 2011 AGA Institute Terms and Conditions

Figure 2 The prevalence of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic fatty liver disease (NASH) among the entire study cohort was 46% and 12.2%, respectively. The prevalence of NAFLD varied among different ethnic groups. The prevalence of NASH among patients identified as having fatty liver on ultrasound was 29.9%. Gastroenterology 2011 140, 124-131DOI: (10.1053/j.gastro.2010.09.038) Copyright © 2011 AGA Institute Terms and Conditions

Figure 3 Insulin and alanine aminotransferase (ALT) were found to be independently predictive of nonalcoholic fatty liver disease (NASH). Using these variables, an equation was created to predict NASH with a receiver operating characteristic of 0.806 (95% CI: 0.72−0.89; P < .001). Using a cut-off value of −0.806 derived from equation, the sensitivity and specificity are approximately equal to 75%. Subsequently, a probability curve for insulin and ALT for detecting NASH was created. Gastroenterology 2011 140, 124-131DOI: (10.1053/j.gastro.2010.09.038) Copyright © 2011 AGA Institute Terms and Conditions

Figure 4 The prevalence of nonalcoholic fatty liver disease (NASH) varied among ethnic groups. Hispanics had the highest prevalence, followed by African Americans and Caucasians. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; NAFLD, nonalcoholic fatty liver disease; NASH, nonalcoholic steatohepatitis. Gastroenterology 2011 140, 124-131DOI: (10.1053/j.gastro.2010.09.038) Copyright © 2011 AGA Institute Terms and Conditions