Long-term Effect of Chronic Oral Anticoagulation with Warfarin after Acute Myocardial Infarction Salman A. Haq, MD, John F. Heitner, MD, Terrence J.

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Long-term Effect of Chronic Oral Anticoagulation with Warfarin after Acute Myocardial Infarction Salman A. Haq, MD, John F. Heitner, MD, Terrence J. Sacchi, MD, Sorin J. Brener, MD The American Journal of Medicine Volume 123, Issue 3, Pages 250-258 (March 2010) DOI: 10.1016/j.amjmed.2009.08.016 Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 1 Study inclusion and exclusion process. OAC=oral anticoagulation. The American Journal of Medicine 2010 123, 250-258DOI: (10.1016/j.amjmed.2009.08.016) Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 2 Forester plot of effect of long-term oral anticoagulation on mortality (point estimate proportional to number of events, odds ratio <1 indicates benefit for oral anticoagulation). OAC=oral anticoagulation; ATACS=Antithrombotic Therapy in Acute Coronary Syndromes Study; WARIS=Warfarin Aspirin Re-infarction Study; AFTER=Aspirin/Anticoagulants Following Thrombolysis with Eminase in Recurrent infarction study; CARS=Coumadin Aspirin Reinfarction Study; ASPECT=Aspirin and Coumadin after Acute Coronary Syndromes study; CHAMP=Combination Hemotherapy and Mortality Prevention study; APRICOT=Antithrombotics in the Prevention of Reocclusion In Coronary Thrombolysis; LoWASA=Effect of fixed low-dose warfarin added to aspirin in the long term after acute myocardial infarction study. The American Journal of Medicine 2010 123, 250-258DOI: (10.1016/j.amjmed.2009.08.016) Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 3 Forester plot of effect of long-term oral anticoagulation on nonfatal stroke (point estimate proportional to number of events, odds ratio <1 indicates benefit for oral anticoagulation). OAC=oral anticoagulation; WARIS=Warfarin Aspirin Re-infarction Study; CARS=Coumadin Aspirin Reinfarction Study; ASPECT=Aspirin and Coumadin after Acute Coronary Syndromes study; CHAMP=Combination Hemotherapy and Mortality Prevention study; LoWASA=Effect of fixed low-dose warfarin added to aspirin in the long term after acute myocardial infarction study. The American Journal of Medicine 2010 123, 250-258DOI: (10.1016/j.amjmed.2009.08.016) Copyright © 2010 Elsevier Inc. Terms and Conditions

Figure 4 Forester plot of effect of long-term oral anticoagulation on nonfatal major bleeding (point estimate proportional to number of events, odds ratio >1 indicates excess with oral anticoagulation). OAC=oral anticoagulation; WARIS=Warfarin Aspirin Re-infarction Study; ATACS=Antithrombotic Therapy in Acute Coronary Syndromes Study; CARS=Coumadin Aspirin Reinfarction Study; ASPECT=Aspirin and Coumadin after Acute Coronary Syndromes study; CHAMP=Combination Hemotherapy and Mortality Prevention study; APRICOT=Antithrombotics in the Prevention of Reocclusion In Coronary Thrombolysis; LoWASA=Effect of fixed low-dose warfarin added to aspirin in the long term after acute myocardial infarction study. The American Journal of Medicine 2010 123, 250-258DOI: (10.1016/j.amjmed.2009.08.016) Copyright © 2010 Elsevier Inc. Terms and Conditions