Defining the GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for Primate GvHD Pathogenesis and the Mechanisms of Partial.

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Presentation transcript:

Defining the GvHD Transcriptome: Network Analysis Identifies the Key Pathways Responsible for Primate GvHD Pathogenesis and the Mechanisms of Partial GvHD Control with Sirolimus Natalia Kozyr, Carly Ziegler, Swetha Ramakrishnan, Aneesah Polnett, Kelly Hamby, Taylor Deane, Linda Stempora, Bruce R. Blazar, Leslie S. Kean Biology of Blood and Marrow Transplantation Volume 19, Issue 2, Pages S328-S329 (February 2013) DOI: 10.1016/j.bbmt.2012.11.498 Copyright © 2013 Terms and Conditions

Figure 1 The Primate GvHD Transcriptome: (A) Principal Component Analysis (PCA) reveals that maximal variation between the arrays was determined by the experimental cohort. (B) Differentially Expressed (DE) Genes Compared to Healthy Controls (HC). Left: Shown Are numbers of Up- (red) and Down- (blue) regulated genes in Auto, Sirolimus, and GvHD cohorts compared to HC. Right: Venn Diagrams showing overlap of DE genes between the three cohorts. (C) Ingenuity Pathway Analysis depicting gene networks differentially regulated during GvHD. Shown are representative networks showing cell cycle (left) and inflammatory response genes (right). Biology of Blood and Marrow Transplantation 2013 19, S328-S329DOI: (10.1016/j.bbmt.2012.11.498) Copyright © 2013 Terms and Conditions