PTEN and PIK3CA Expression Is Associated with Prolonged Survival after Gefitinib Treatment in EGFR-Mutated Lung Cancer Patients Hideki Endoh, MD, PhD,

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PTEN and PIK3CA Expression Is Associated with Prolonged Survival after Gefitinib Treatment in EGFR-Mutated Lung Cancer Patients Hideki Endoh, MD, PhD, Yasushi Yatabe, MD, PhD, Takayuki Kosaka, MD, Hiroyuki Kuwano, MD, PhD, Tetsuya Mitsudomi, MD, PhD Journal of Thoracic Oncology Volume 1, Issue 7, Pages 629-634 (September 2006) DOI: 10.1016/S1556-0864(15)30374-9 Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Effect of EGFR mutations (A) and KRAS mutations (B) on survival of patients who received gefitinib treatment. Journal of Thoracic Oncology 2006 1, 629-634DOI: (10.1016/S1556-0864(15)30374-9) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Effect of expression of EGFR (A), PIK3CA (B), and PTEN (C) gene expression status on survival of patients who received gefitinib treatment. Cutoff values of expression were median (i.e., 0.915 for EGFR, 0.324 for PIK3CA, and 0.152 for PTEN). Journal of Thoracic Oncology 2006 1, 629-634DOI: (10.1016/S1556-0864(15)30374-9) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Combined effect of EGFR mutation and PIK3CA expression (A) or EGFR mutation and PTEN expression (B) on survival of patients who received gefitinib treatment. Journal of Thoracic Oncology 2006 1, 629-634DOI: (10.1016/S1556-0864(15)30374-9) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions