The last 80 years in primary immunodeficiency: How far have we come, how far need we go?  William T. Shearer, MD, PhD, Alain Fischer, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 117, Issue 4, Pages 748-752 (April 2006) DOI: 10.1016/j.jaci.2006.02.029 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 The world of primary immunodeficiency: the last 80 years. Early depiction of patients with ataxia telangiectasia (reprinted from Syllaba and Henner, 2006,1 with permission) and current photographs of an adult patient with CVID receiving IVIG replacement (with permission, courtesy of Dr Celine Hanson, Texas Children's Hospital, Houston, Tex) and a boy with partial immunoreconstitution of X-linked SCID receiving gene replacement (with permission, courtesy of Drs Harry Malech and Jennifer Puck, National Institutes of Health, Bethesda, Md). See also the front cover of the Journal. Journal of Allergy and Clinical Immunology 2006 117, 748-752DOI: (10.1016/j.jaci.2006.02.029) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions