Pushing and Pulling on Adult Neural Stem Cells

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Presentation transcript:

Pushing and Pulling on Adult Neural Stem Cells Albina Ibrayeva, Michael A. Bonaguidi Cell Stem Cell Volume 16, Issue 5, Pages 451-452 (May 2015) DOI: 10.1016/j.stem.2015.04.011 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Hippocampal Neural Stem Cell Plasticity in Response to Graded Epilepsy Models Sierra et al. (2015) reveal that transient epileptiform activity (EA) induces rNSC activation to promote a transient increase in neurogenesis, which leads to premature stem cell depletion. During sustained mesial temporal lobe epilepsy (MTLE), rNSCs undergo high rates of activation, switch their fate decisions, and differentiate into reactive astrocytes to massively decrease neurogenesis. Illustration by Kristen L. Chen. Cell Stem Cell 2015 16, 451-452DOI: (10.1016/j.stem.2015.04.011) Copyright © 2015 Elsevier Inc. Terms and Conditions