Luca Sartori, Saverio Minucci Chemistry & Biology

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Tackling Oxidative Stress by a Direct Route: A New Job for HDAC Inhibitors? Luca Sartori, Saverio Minucci Chemistry & Biology Volume 22, Issue 4, Pages 431-432 (April 2015) DOI: 10.1016/j.chembiol.2015.04.003 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 A Schematic View of the Activity of Some Hydroxamic Acid-Based HDAC Inhibitors, Such as Panobinostat/LBH-589 (A) At concentrations below 1 μM, close to those used in clinic, panobinostat acts by inhibiting HDACs, which leads to increased levels of histone acetylation and transcriptional changes that result in enhanced protection from oxidative stress. HDACi, HDAC inhibitor. (B) At concentrations above 1 μM, panobinostat and some other hydroxamic acid-based HDAC inhibitors exhibit an additional activity that protect against oxidative stress as they directly catalyze conversion of hydrogen peroxide to water. Chemistry & Biology 2015 22, 431-432DOI: (10.1016/j.chembiol.2015.04.003) Copyright © 2015 Elsevier Ltd Terms and Conditions