Screening for a Diamond in the Rough

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Presentation transcript:

Screening for a Diamond in the Rough Xiaoqian Wu, Julian G. Hurdle Chemistry & Biology Volume 20, Issue 9, Pages 1091-1092 (September 2013) DOI: 10.1016/j.chembiol.2013.09.002 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 Screening and Preclinical Path for Hits Dissipating the Membrane’s Electrical Potential—Δψ—or Proton Gradient—ΔpH The inset simplifies the membrane and respiratory chain as drug target sites; compounds are shown as colored triangles; not shown is the peptidoglycan and unknown membrane-embedded proteins that could interact with membrane-active agents. The DiSC3(5) florescence data in the graph was derived from Farha et al. (2013). Chemistry & Biology 2013 20, 1091-1092DOI: (10.1016/j.chembiol.2013.09.002) Copyright © 2013 Elsevier Ltd Terms and Conditions