Relative Risk of Myopathy Associated with Selected Baseline Characteristics among 6031 Participants Assigned to 80 mg of Simvastatin Daily in SEARCH The.

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Relative Risk of Myopathy Associated with Selected Baseline Characteristics among 6031 Participants Assigned to 80 mg of Simvastatin Daily in SEARCH The SEARCH Collaborative Group. N Engl J Med 2008;359:[Epub Jul 23]

Genomic Regions Associated with Myopathy in the Genomewide Association Study* The SEARCH Collaborative Group. N Engl J Med 2008;359:[Epub Jul 23]

Results of Tests for a Trend in the Association between Myopathy and Each SNP Measured in the Genome-wide Association Study P values are shown for each SNP measured among 85 participants with myopathy and 90 matched controls who were taking 80 mg of simvastatin daily. Analyses are based on 316,184 of the 318,237 SNPs (99.4%) on the Sentrix HumanHap300-Duo BeadChip (Illumina). A result above the horizontal red line indicates strong evidence of an association (P<5×10-7). The SEARCH Collaborative Group. N Engl J Med 2008;359:[Epub Jul 23]

Odds Ratios for Myopathy Associated with the SLCO1B1 rs4149056 Genotype among Subgroups of Patients Taking 80 mg of Simvastatin Daily Black squares indicate odds ratios (with area proportional to the amount of statistical information in each subdivision), and horizontal lines indicate 95% CIs (ending with an arrowhead when the CI extends beyond the scale). The overall odds ratio and its 95% CI are indicated by an unshaded diamond. The SEARCH Collaborative Group. N Engl J Med 2008;359:[Epub Jul 23]

Estimated Cumulative Risk of Myopathy Associated with Taking 80 mg of Simvastatin Daily, According to SLCO1B1 rs4149056 Genotype The SEARCH Collaborative Group. N Engl J Med 2008;359:[Epub Jul 23]