A comparison of the SNAP II™ and BIS XP™ indices during sevoflurane and nitrous oxide anaesthesia at 1 and 1.5 MAC and at awakening Wong C.A. , Fragen.

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A comparison of the SNAP II™ and BIS XP™ indices during sevoflurane and nitrous oxide anaesthesia at 1 and 1.5 MAC and at awakening Wong C.A. , Fragen R.J. , Fitzgerald P , McCarthy R.J. British Journal of Anaesthesia Volume 97, Issue 2, Pages 181-186 (August 2006) DOI: 10.1093/bja/ael131 Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 1 SNAP and BIS indices at different time intervals in subjects receiving sevoflurane. MAC, minimum alveolar concentration equivalent; D/C, discontinuation of anaesthesia; 1-PTA, 1 min before awakening; awakening, eye opening in response to verbal request. †P<0.05 compared with baseline, ‡P<0.05 compared with BIS. British Journal of Anaesthesia 2006 97, 181-186DOI: (10.1093/bja/ael131) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 2 SNAP and BIS indices at different time intervals in subjects receiving sevoflurane with nitrous oxide. MAC, minimum alveolar concentration equivalent; D/C, discontinuation of anaesthesia; 1-PTA, 1 min before awakening; awakening, eye opening in response to verbal request. †P<0.05 compared with baseline, ‡P<0.05 compared with BIS. British Journal of Anaesthesia 2006 97, 181-186DOI: (10.1093/bja/ael131) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions

Fig 3 Scattergram of SNAP and BIS values vs end-tidal (Et) sevoflurane concentrations recorded every minute from the time of discontinuation of anaesthesia until eye opening in response to verbal request. Line plots are predicted index values vs end-tidal sevoflurane concentration determined by fitting these data to a Hill equation. The equation was E=Emin+(Emax−Emin)/[(1+(E′sevo/EC50)γ], where E was the index value, Emax and Emin the highest and lowest index values respectively, E′sevo the end-tidal sevoflurane concentration, EC50 the end-tidal sevoflurane concentration associated with a half maximal effect and γ is the Hillslope. British Journal of Anaesthesia 2006 97, 181-186DOI: (10.1093/bja/ael131) Copyright © 2006 British Journal of Anaesthesia Terms and Conditions