Complicated Tails: Histone Modifications and the DNA Damage Response

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Complicated Tails: Histone Modifications and the DNA Damage Response Genevieve M. Vidanes, Carla Y. Bonilla, David P. Toczyski Cell Volume 121, Issue 7, Pages 973-976 (July 2005) DOI: 10.1016/j.cell.2005.06.013 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 Models of Recruitment to a DSB via Histone Modifications (A) γ-H2AX is induced by DSBs to recruit cohesins, chromatin remodeling complexes, and checkpoint adaptors to the damage site. The H3-K79-Me (H4-K20-Me in S. pombe) is a constitutive modification that contributes to recruiting checkpoint adaptors to DSBs. (B) (Ba) The ATM kinase is recruited to the broken end through the MRN complex, where it mediates H2AX phosphorylation. (Bb) After the initiation of resection, both ATR (and its associated ATRIP subunit) and 9-1-1 are recruited to the resected ssDNA. ATR phosphorylates the adaptor protein and expands upon the initial H2AX phosphorylation. Chromatin remodeling complexes are recruited to γ-H2AX. (Bc) Chromatin remodelers may facilitate presentation of H3/H4 methylations. (Bd) Adaptors could interact cooperatively with H3/H4 methylation and γ-H2AX. Cell 2005 121, 973-976DOI: (10.1016/j.cell.2005.06.013) Copyright © 2005 Elsevier Inc. Terms and Conditions