Photosensitivity in Rheumatic Diseases Victoria P. Werth, Muhammad Bashir, Wei Zhang  Journal of Investigative Dermatology Symposium Proceedings  Volume 9, Issue 1, Pages 57-63 (January 2004) DOI: 10.1111/j.1087-0024.2004.00839.x Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Model for pathogenesis of photosensitive autoimmune disease. Apoptotic cells are normally cleared by noninflammatory pathways that involve macrophages. In the presence of a number of genetic polymorphisms that lead to overexpression or underexpression of proteins involved in promoting apoptosis or impairing clearance of apoptotic cells, marked with *, various immune effector pathways that increase apoptotic death are triggered, as outlined in the box. Journal of Investigative Dermatology Symposium Proceedings 2004 9, 57-63DOI: (10.1111/j.1087-0024.2004.00839.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Skin biopsy showing TUNEL + apoptotic keratinocytes in (a) UVA-irradiated skin 48 hours after irradiation (20 J/cm2), but not in (b) sham-irradiated normal skin. Journal of Investigative Dermatology Symposium Proceedings 2004 9, 57-63DOI: (10.1111/j.1087-0024.2004.00839.x) Copyright © 2004 The Society for Investigative Dermatology, Inc Terms and Conditions