Pirfenidone-Induced Sarcoid-Like Reaction

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Pirfenidone-Induced Sarcoid-Like Reaction Nicholas A. Kolaitis, MD, Jasleen Kukreja, MD, Kirk D. Jones, MD, Steven R. Hays, MD, Lorriana E. Leard, MD CHEST Volume 154, Issue 4, Pages e89-e92 (October 2018) DOI: 10.1016/j.chest.2018.03.048 Copyright © 2018 Terms and Conditions

Figure 1 CT and PET CT scans showing development of diffuse hypermetabolic lymphadenopathy after starting pirfenidone. A, Soft tissue window prior to starting pirfenidone. B, Lung window prior to starting pirfenidone. C, PET-CT after starting pirfenidone. D, Soft tissue window after starting pirfenidone. CHEST 2018 154, e89-e92DOI: (10.1016/j.chest.2018.03.048) Copyright © 2018 Terms and Conditions

Figure 2 Histology from mediastinal lymph node excisional biopsy and explant of lung. A, Low-power view of lymph node biopsy with non-necrotizing granulomas. B, High-power view of lymph node biopsy with non-necrotizing granulomas. C, Low-power view of usual interstitial pneumonia pattern from lung explant. D, High-power view of usual interstitial pneumonia pattern from lung explant. CHEST 2018 154, e89-e92DOI: (10.1016/j.chest.2018.03.048) Copyright © 2018 Terms and Conditions

Figure 3 CT scan after lung transplant showing resolution of lymphadenopathy after withdrawal of pirfenidone. CHEST 2018 154, e89-e92DOI: (10.1016/j.chest.2018.03.048) Copyright © 2018 Terms and Conditions