Volume 16, Issue 3, Pages (September 2009)

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Volume 16, Issue 3, Pages 180-182 (September 2009) SDH5 Mutations and Familial Paraganglioma: Somewhere Warburg is Smiling William G. Kaelin Cancer Cell Volume 16, Issue 3, Pages 180-182 (September 2009) DOI: 10.1016/j.ccr.2009.08.013 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Potential Links Between Krebs Cycle and 2-Oxoglutarate-dependent Dioxygenase Activity For simplicity, individual subunits of multimeric complexes are not shown. Increased activity (red triangle in meter) of certain 2-oxoglutarate-dependent dioxygenases, such as the proapoptotic prolyl hydroxylase PHD3 (EglN3), is envisioned to suppress tumor formation. Mutations affecting SDH or FH promote the accumulation of succinate and fumarate, respectively, which suppress the catalytic activity of 2-oxoglutarate-dependent dioxygenases. Cancer Cell 2009 16, 180-182DOI: (10.1016/j.ccr.2009.08.013) Copyright © 2009 Elsevier Inc. Terms and Conditions