Eppur Si Muove! The 2013 Nobel Prize in Chemistry

Slides:

Advertisements

Similar presentations

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB Sonja Baumli, Jane A. Endicott, Louise N. Johnson Chemistry & Biology Volume 17, Issue.

Advertisements

Early Folding Events Protect Aggregation-Prone Regions of a β-Rich Protein Ivan L. Budyak, Beena Krishnan, Anna M. Marcelino-Cruz, Mylene C. Ferrolino,

Binocular rivalry Colin W.G. Clifford Current Biology Volume 19, Issue 22, Pages R1022-R1023 (December 2009) DOI: /j.cub Copyright ©

Development of Antibiotic Activity Profile Screening for the Classification and Discovery of Natural Product Antibiotics Weng Ruh Wong, Allen G. Oliver,

Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction Michal Bista, Siglinde Wolf, Kareem Khoury, Kaja Kowalska, Yijun Huang, Ewa.

Site-Directed Mutagenesis Demonstrates the Plasticity of the β Helix: Implications for the Structure of the Misfolded Prion Protein Jay H. Choi, Barnaby.

How do emotion and motivation direct executive control? Luiz Pessoa Trends in Cognitive Sciences Volume 13, Issue 4, Pages (April 2009) DOI: /j.tics

A Gαq-Ca2+ Signaling Pathway Promotes Actin-Mediated Epidermal Wound Closure in C. elegans Suhong Xu, Andrew D. Chisholm Current Biology Volume 21, Issue.

Conformational Analysis of NMDA Receptor GluN1, GluN2, and GluN3 Ligand-Binding Domains Reveals Subtype-Specific Characteristics Yongneng Yao, John Belcher,

Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &

Two views of brain function Marcus E. Raichle Trends in Cognitive Sciences Volume 14, Issue 4, Pages (April 2010) DOI: /j.tics

Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis Tim J. Wigle, Laurel M. Provencher, Jacqueline.

Biocompatible Quantum Dots for Biological Applications Sandra J. Rosenthal, Jerry C. Chang, Oleg Kovtun, James R. McBride, Ian D. Tomlinson Chemistry &

Human Brown Adipose Tissue Sven Enerbäck Cell Metabolism Volume 11, Issue 4, Pages (April 2010) DOI: /j.cmet Copyright © 2010.

Toward a Structure Determination Method for Biomineral-Associated Protein Using Combined Solid- State NMR and Computational Structure Prediction David.

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Alexei F. Kisselev, Wouter A. van der Linden, Herman S. Overkleeft Chemistry & Biology.

Structure of the Hepatitis C Virus IRES Bound to the Human 80S Ribosome: Remodeling of the HCV IRES Daniel Boehringer, Rolf Thermann, Antje Ostareck-Lederer,

Staphylococcus aureus and Bacillus subtilis W23 Make Polyribitol Wall Teichoic Acids Using Different Enzymatic Pathways Stephanie Brown, Timothy Meredith,

A Plug Release Mechanism for Membrane Permeation by MLKL Lijing Su, Bradley Quade, Huayi Wang, Liming Sun, Xiaodong Wang, Josep Rizo Structure Volume 22,

How surgeons can find information online? Martin Hewitt International Journal of Surgery Volume 5, Issue 6, Pages (December 2007) DOI: /j.ijsu

Recognizing Protein-Ligand Binding Sites by Global Structural Alignment and Local Geometry Refinement Ambrish Roy, Yang Zhang Structure Volume 20, Issue.

Crohn's disease Prof Daniel C Baumgart, MD, Prof William J Sandborn, MD The Lancet Volume 380, Issue 9853, Pages (November 2012) DOI: /S (12)

Thank God for Richard Dawkins?

Nucleosomes and Cisplatin

Computer-Based Redesign of a β Sandwich Protein Suggests that Extensive Negative Design Is Not Required for De Novo β Sheet Design Xiaozhen Hu, Huanchen.

Heads Up S-Layer Display: The Power of Many

Adam W. Van Wynsberghe, Qiang Cui Structure

The commercial determinants of health

Nucleosomes and Cisplatin

Heads Up S-Layer Display: The Power of Many

“Seeing” the Invisibles at the Single-Molecule Level

Antibiotics: A New Hope

Foundations for Directed Alkaloid Biosynthesis

Cell Walls: Monitoring Integrity with THE Kinase

Adding Specificity to Artificial Transcription Activators

Finding the Missing Code of RNA Recognition by PUF Proteins

Volume 13, Issue 12, Pages (December 2005)

Amyloid Structures from Alzheimer’s Disease Patients

Gene therapy—where are we?

Membrane Insertases Are Present in All Three Domains of Life

The Gobi Desert medical kit

JAK3 Specific Kinase Inhibitors: When Specificity Is Not Enough

Organisation of the care of patients with heart failure

Volume 20, Issue 8, Pages v-vi (August 2012)

Sirtuins Caught in the Act

Volume 362, Pages s6-s7 (December 2003)

What would happen if we stopped vaccination?

No Need To Be Pure: Mix the Cultures!

Volume 20, Issue 6, Pages (June 2012)

MicroRNAs in Memory Processing

Telling it like it isn't: truth and lies in a post-9/11 world

Making a New Turn In Matrix Metalloprotease Inhibition

Thank God for Richard Dawkins?

Circular Proteins: Ring around with NOESY

Foundations for Directed Alkaloid Biosynthesis

Proteins in Plant Brassinosteroid Signaling

Amyloid Structures from Alzheimer’s Disease Patients

Tool Use: Crows Craft the Right Tool for the Job

L-DOPA Ropes in tRNAPhe

Reviewer Acknowledgment

Plasma Lactescence in Acute Pancreatitis

Autophagy: Nobel Prize 2016 and allergy and asthma research

Volume 21, Issue 9, Pages (September 2014)

Cryptic No Longer: Arrays of CLASP1 TOG Domains

Improving management of neonatal infections

Tools to Tackle Protein Acetylation

Volume 21, Issue 9, Pages (September 2014)

Gene Regulation in the Postgenomic Era: Technology Takes the Wheel

Volume 23, Issue 1, Pages vii-ix (January 2015)

Presentation transcript:

Eppur Si Muove! The 2013 Nobel Prize in Chemistry Jeremy C. Smith, Benoît Roux Structure Volume 21, Issue 12, Pages 2102-2105 (December 2013) DOI: 10.1016/j.str.2013.11.005 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 Biomolecular Simulation Systems in the 1970s and Now (A) Bovine pancreatic trypsin inhibitor: the subject of the first published MD simulation of a protein (McCammon et al., 1977). (B) Modern-day multimillion-atom simulation model of lignocellulosic biomass with cellulose (green), lignin (brown), and hemicellulose (green strands). Structure 2013 21, 2102-2105DOI: (10.1016/j.str.2013.11.005) Copyright © 2013 Elsevier Ltd Terms and Conditions