Possible Impact of Cytomegalovirus-Specific CD8+ T Cells on Immune Reconstitution and Conversion to Complete Donor Chimerism after Allogeneic Stem Cell.

Slides:

Advertisements

Similar presentations

Cytomegalovirus Status and the Outcome of T Cell–Replete Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation Frans M. Verduyn Lunel,

Advertisements

Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-versus-Host Disease after Allogeneic Stem Cell.

Navneet S. Majhail, Todd DeFor, Hillard M. Lazarus, Linda J. Burns

Immune Reconstitution in Recipients of Photodepleted HLA-Identical Sibling Donor Stem Cell Transplantations: T Cell Subset Frequencies Predict Outcome

Increased Plasma Indoleamine 2,3-Dioxygenase Activity and Interferon-γ Levels Correlate with the Severity of Acute Graft-versus-Host Disease after Allogeneic.

Increased Levels of Tumor Necrosis Factor α Are Associated with an Increased Risk of Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell.

Vaccination of Children following Allogeneic Stem Cell Transplantation

Early Cytomegalovirus Reactivation Leaves a Specific and Dynamic Imprint on the Reconstituting T Cell Compartment Long-Term after Hematopoietic Stem Cell.

Patient HLA-DP–Specific CD4+ T Cells from HLA-DPB1–Mismatched Donor Lymphocyte Infusion Can Induce Graft-versus-Leukemia Reactivity in the Presence or.

Humoral Immune Reconstitution Kinetics after Allogeneic Hematopoietic Stem Cell Transplantation in Children: A Maturation Block of IgM Memory B Cells.

Early CMV Viremia Is Associated with Impaired Viral Control following Nonmyeloablative Hematopoietic Cell Transplantation with a Total Lymphoid Irradiation.

High Rabbit-Antihuman Thymocyte Globulin Levels Are Associated with Low Likelihood of Graft-vs-Host Disease and High Likelihood of Posttransplant Lymphoproliferative.

Up-regulation of NK Cell Activating Receptors Following Allogeneic Hematopoietic Stem Cell Transplantation under a Lymphodepleting Reduced Intensity Regimen.

Combined CD4+ Donor Lymphocyte Infusion and Low-Dose Recombinant IL-2 Expand FOXP3+ Regulatory T Cells following Allogeneic Hematopoietic Stem Cell Transplantation

KIR2DS4 and Its Variant KIR1D Are Associated with Acute Graft-versus-Host Disease, Cytomegalovirus, and Overall Survival after Sibling-Related HLA-Matched.

Mixed T Cell Chimerism After Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia Using an Alemtuzumab-Containing Regimen Is.

Chimerism studies in HLA-identical nonmyeloablative hematopoietic stem cell transplantation point to the donor CD8+ T-cell count on day +14 as a predictor.

Busulfan, Fludarabine, and Alemtuzumab As a Reduced Toxicity Regimen for Children with Malignant and Nonmalignant Diseases Improves Engraftment and Graft-versus-

Navneet S. Majhail, Todd DeFor, Hillard M. Lazarus, Linda J. Burns

Early Human Herpesvirus Type 6 Reactivation after Allogeneic Stem Cell Transplantation: A Large-Scale Clinical Study Rémy Dulery, Julia Salleron, Anny.

Human Herpesvirus-6B Reactivation Is a Risk Factor for Grades II to IV Acute Graft- versus-Host Disease after Hematopoietic Stem Cell Transplantation:

Association of Disparities in Known Minor Histocompatibility Antigens with Relapse-Free Survival and Graft-versus-Host Disease after Allogeneic Stem Cell.

CD161+ T Cells as Predictive Markers for Acute Graft-versus-Host Disease Sung-Eun Lee, Ji-Young Lim, Jae-Ho Yoon, Seung-Hwan Shin, Byung-Sik Cho, Ki-Seong.

Cytomegalovirus Immune Reconstitution Occurs in Recipients of Allogeneic Hematopoietic Cell Transplants Irrespective of Detectable Cytomegalovirus Infection

Cytomegalovirus Infection in Pediatric Hematopoietic Stem Cell Transplantation: Risk Factors for Primary Infection and Cases of Recurrent and Late Infection.

Vascular Endothelial Growth Factor and Activin-A Serum Levels Following Allogeneic Hematopoietic Stem Cell Transplantation David Nachbaur, Petra Schumacher,

Peripheral Blood Grafts from Unrelated Donors Are Associated with Increased Acute and Chronic Graft-versus-Host Disease without Improved Survival Mary.

Erratum to “Increased Type 1 Immune Response in the Bone Marrow Immune Microenvironment of Patients with Poor Graft Function after Allogeneic Hematopoietic.

Increased Programmed Death-1 Molecule Expression in Cytomegalovirus Disease and Acute Graft-versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation

Immune Reconstitution after Allogeneic Hematopoietic Cell Transplantation in Children Coco de Koning, Maud Plantinga, Paul Besseling, Jaap Jan Boelens,

Donor-to-Recipient ABO Mismatch Does Not Impact Outcomes of Allogeneic Hematopoietic Cell Transplantation Regardless of Graft Source Sharat Damodar,

Cytomegalovirus Infection after Allogeneic Transplantation: Comparison of Cord Blood with Peripheral Blood and Marrow Graft Sources Christopher M. Walker,

Lymphocyte Subset Recovery and Outcome after Autologous Hematopoietic Stem Cell Transplantation for Plasma Cell Myeloma Jessica Rueff, Michael Medinger,

Torquetenovirus Dynamics and Immune Marker Properties in Patients Following Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Longitudinal.

Sarah Nikiforow, Jerome Ritz

Rituximab Treatment before Reduced-Intensity Conditioning Transplantation Associates with a Decreased Incidence of Extensive Chronic GVHD Suzanne van.

Correlation between the numbers of naive T cells infused with blood stem cell allografts and the counts of naive T cells after transplantation Jan Storek,

Nasal Epithelial Cells of Donor Origin after Allogeneic Hematopoietic Cell Transplantation are Generated at a Faster Rate in the First 3 Months Compared.

B Cells and Transplantation: An Educational Resource

Fludarabine and 2-Gy TBI is Superior to 2 Gy TBI as Conditioning for HLA-Matched Related Hematopoietic Cell Transplantation: A Phase III Randomized Trial

Is There a Role for Autologous Stem Cell Transplantation for Patients with Acute Myelogenous Leukemia? A Retrospective Analysis Nicolas Novitzky, Valda.

Low-Dose Total Body Irradiation and Fludarabine Conditioning for HLA Class I- Mismatched Donor Stem Cell Transplantation and Immunologic Recovery in Patients.

Cellular Immune Reconstitution and Its Impact on Clinical Outcome in Children with β Thalassemia Major Undergoing a Matched Related Myeloablative Allogeneic.

Evaluation of Angiopoietins and Cell-Derived Microparticles after Stem Cell Transplantation Shosaku Nomura, Kazuyoshi Ishii, Norihito Inami, Yutaka Kimura,

Favorable Overall Survival with Fully Myeloablative Allogeneic Stem Cell Transplantation for Follicular Lymphoma John Kuruvilla, Gregory Pond, Richard.

Post-Transplantation B Cell Activating Factor and B Cell Recovery before Onset of Chronic Graft-versus-Host Disease Caron A. Jacobson, Lixian Sun, Haesook.

Sabina Kersting, Ronald J. Hené, Hein A. Koomans, Leo F. Verdonck

Persistence of host dendritic cells after transplantation is associated with graft-versus- host disease Geoffrey W. Chan, Gullu Gorgun, Kenneth B. Miller,

Protective Immunity Transferred by Infusion of Cytomegalovirus-Specific CD8+ T Cells within Donor Grafts: Its Associations with Cytomegalovirus Reactivation.

Impact of Alemtuzumab Scheduling on Graft-versus-Host Disease after Unrelated Donor Fludarabine and Melphalan Allografts Kile Green, Kim Pearce, Rob.

Costs and Cost-Effectiveness of Allogeneic Stem Cell Transplantation in Children Are Predictable Susanne Matthes-Martin, Ulrike Pötschger, Ronald Barr,

Impact of Donor and Recipient Cytomegalovirus Serostatus on Outcomes of Antithymocyte Globulin–Conditioned Hematopoietic Cell Transplantation Amit Kalra,

CD3+/Tregs Ratio in Donor Grafts Is Linked to Acute Graft-versus-Host Disease and Immunologic Recovery after Allogeneic Peripheral Blood Stem Cell Transplantation

Efficient Stem Cell Collection after Modified Cisplatin-Based Mobilization Chemotherapy in Patients with Diffuse Large B Cell Lymphoma Katharina Lisenko,

Non-CD34+ Cells, Especially CD8+ Cytotoxic T Cells and CD56+ Natural Killer Cells, Rather Than CD34 Cells, Predict Early Engraftment and Better Transplantation.

Immune Reconstitution in Recipients of Photodepleted HLA-Identical Sibling Donor Stem Cell Transplantations: T Cell Subset Frequencies Predict Outcome

High Incidence of Severe Acute Graft-Versus-Host Disease with Tacrolimus and Mycophenolate Mofetil in a Large Cohort of Related and Unrelated Allogeneic.

Chimeric Antigen Receptor–Modified T Cells: Clinical Translation in Stem Cell Transplantation and Beyond Stanley R. Riddell, Michael C. Jensen, Carl.

Systemic Toxoplasmosis Post Allogeneic Stem Cell Transplantation (Allo-SCT): Lessons Learned from HIV? Marie von Lilienfeld-Toal, MD, Maria Gilleece,

Blood and Marrow Transplant Handbook

Differences in T Cell Depletion and Intestinal Mucositis Explain Inconsistent Effects of NOD2/CARD15 Polymophisms in SCT W.J.F.M. van der Velden, J.P.

Young Female Donors Do Not Increase the Risk of Graft-versus-Host Disease or Impact Overall Outcomes in Pediatric HLA-Matched Sibling Hematopoietic Stem.

Low Serum Levels of Total Rabbit-IgG Is Associated with Acute Graft-Versus-Host Disease after Unrelated Donor Hematopoietic Stem Cell Transplantation:

Varicella-Zoster Virus Disease Is More Frequent after Cord Blood Than after Bone Marrow Transplantation Kristel Vandenbosch, Philippe Ovetchkine, Martin.

Reversal of Low Donor Chimerism after Hematopoietic Cell Transplantation Using Pentostatin and Donor Lymphocyte Infusion: A Prospective Phase II Multicenter.

Mammen Chandy Biology of Blood and Marrow Transplantation

Prospective Monitoring of Tumor Necrosis Factor α and Interferon γ to Predict the Onset of Acute and Chronic Graft-versus-Host Disease after Allogeneic.

A Phase I Study in Adults of Clofarabine Combined with High-Dose Melphalan as Reduced-Intensity Conditioning for Allogeneic Transplantation Mark H. Kirschbaum,

Graft-Derived Reconstitution of Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation Abir Bhattacharyya, Laïla-Aïcha.

Futility of Relapsed Diffuse Large B Cell Lymphoma Transplantation?

Presentation transcript:

Possible Impact of Cytomegalovirus-Specific CD8+ T Cells on Immune Reconstitution and Conversion to Complete Donor Chimerism after Allogeneic Stem Cell Transplantation Justyna Ogonek, Pavankumar Varanasi, Susanne Luther, Patrick Schweier, Wolfgang Kühnau, Gudrun Göhring, Elke Dammann, Michael Stadler, Arnold Ganser, Sylvia Borchers, Ulrike Koehl, Eva M. Weissinger, Lothar Hambach Biology of Blood and Marrow Transplantation Volume 23, Issue 7, Pages 1046-1053 (July 2017) DOI: 10.1016/j.bbmt.2017.03.027 Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Immune reconstitution is faster in patients receiving grafts from CMV-seropositive donor. Course of CD3+ (left), CD8+ (middle), and CD4+ (right) T cell reconstitution in CMV R+/D– patients (open circles) and R+/D+ patients (filled squares) after allo-SCT. The data points indicate mean ± standard error of the mean. Statistical analysis was performed using Mann-Whitney U test, P < .05 are indicated. Biology of Blood and Marrow Transplantation 2017 23, 1046-1053DOI: (10.1016/j.bbmt.2017.03.027) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 The course of CMV-CTL reconstitution after allo-SCT is similar in CMV R+/D– and R+/D+ patients with CMV-CTLs. CMV-CTL reconstitution in the CMV R+/D– and R+/D+ setting is shown in all patients (A and B) or only in patients with >1 CMV-CTL/µl (C). (A and C) The data points indicate mean ± standard error of the mean in R+/D– (open circles) and R+/D+ patients (filled squares). Statistical analysis was performed from month 1 (A) or month 2 (C) after allo-SCT on using Mann-Whitney U test. P < .05 are indicated. (B) The bars indicate percentage of patients with >1 CMV-CTL/µl in R+/D– (open bars) and R+/D+ patients (filled bars). Comparison between groups was performed using Fisher's exact test. P < .05 are indicated. Biology of Blood and Marrow Transplantation 2017 23, 1046-1053DOI: (10.1016/j.bbmt.2017.03.027) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Presence of CMV-CTL is associated with a strong immune reconstitution. (A) CD3+ (left), CD8+ (middle), and CD4+ (right) levels at 3 months after allo-SCT in CMV R+/D– (circles) and R+/D+ (squares) patients without CMV-CTLs (open symbols) and with CMV-CTLs (filled symbols). Data points represent individual patients and horizontal line indicates mean. (B) Course of CD3+ (left), CD8+ (middle), and CD4+ (right) T cell reconstitution in the combined CMV R+/D– and R+/D+ patient cohort without (open triangles) and with CMV-CTLs (filled triangles) after allo-SCT. Data points represent mean ± standard error of the mean. Statistical analysis was performed using Mann-Whitney U test. P < .05 are indicated. Biology of Blood and Marrow Transplantation 2017 23, 1046-1053DOI: (10.1016/j.bbmt.2017.03.027) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 CMV-CTL response positively correlates with the overall T cell recovery in patients with CMV-CTLs. Correlation of CMV-CTL counts (x axis) with CD3+ (left), CD8+ (middle), and CD4+ (right) T cell count (y axis) in (A) CMV R+/D+ patients and (B) CMV R+/D– patients with >1 CMV-CTL/µL within the first 10 months after allo-SCT. Significant differences between groups were assessed by Spearman rank correlation test including 1 not depicted data point located outside the axis limits. P values indicate significance levels, and R indicates the correlation coefficient. Biology of Blood and Marrow Transplantation 2017 23, 1046-1053DOI: (10.1016/j.bbmt.2017.03.027) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 5 Presence of CMV-CTLs is linked to low host chimerism levels. (A) Host chimerism levels at 3 months after allo-SCT in all CMV R+/D– patients (open circles) and R+/D+ patients (filled squares). (B and C) Host chimerism levels at 3 months after allo-SCT in all patients (B) and in patients without aGVHD grades II to IV (C). CMV R+/D– (circles) and R+/D+(squares) patients without CMV-CTLs (open symbols) and with CMV-CTLs (filled symbols) were compared. Data points represent individual patients and the horizontal line indicates mean. Statistical analysis was performed using Mann-Whitney U test. P < .05 are indicated. Biology of Blood and Marrow Transplantation 2017 23, 1046-1053DOI: (10.1016/j.bbmt.2017.03.027) Copyright © 2017 The American Society for Blood and Marrow Transplantation Terms and Conditions