Formin’ a Nuclear Protection Jörg Renkawitz, Michael Sixt  Cell  Volume 167, Issue 6, Pages 1448-1449 (December 2016) DOI: 10.1016/j.cell.2016.11.024 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Mechanical Challenge of the Nucleus During Cell Migration and Its Protection Cells migrating in three-dimensional microenvironments face the challenge of squeezing the nucleus (the largest cellular organelle) through pores. (A) Strong mechanical forces such as by migration through small microenvironmental constrictions can rupture the nuclear envelope and damage the genomic information. (B) To prevent excessive nuclear damage, the intra-nuclear lamin network acts as a shock absorber, and the ESCRT pathway repairs nuclear envelope ruptures. Skau et al. (2016) identified a novel additional mechanism to protect the nucleus, which bases on FMN2-induced perinuclear actin, and increases cell survival and decreases DNA damage. (C) The recent identification of considerable nuclear damage and its cellular protection mechanisms opens a number of important questions to be solved to fully understand how cells cope with the mechanical challenge the nucleus faces during cell migration. Cell 2016 167, 1448-1449DOI: (10.1016/j.cell.2016.11.024) Copyright © 2016 Elsevier Inc. Terms and Conditions