Ee-chun Cheng, Haifan Lin Developmental Cell

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Repressing the Repressor: A lincRNA as a MicroRNA Sponge in Embryonic Stem Cell Self-Renewal Ee-chun Cheng, Haifan Lin Developmental Cell Volume 25, Issue 1, Pages 1-2 (April 2013) DOI: 10.1016/j.devcel.2013.03.020 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 A Competition for miR-145 between linc-RoR and mRNAs Encoding the Core TFs The presence of linc-RoR in hESCs traps miR-145, preventing it from repressing the translation of the core pluripotency factors and ensuring the stem cell fate. The disappearance of linc-RoR in differentiating hESCs releases miR-145, allowing it to repress the translation of core pluripotency factors. Developmental Cell 2013 25, 1-2DOI: (10.1016/j.devcel.2013.03.020) Copyright © 2013 Elsevier Inc. Terms and Conditions