N.A. Manering, T. Reuter, H. Ihmsen, D.C. Yeomans, A. Tzabazis

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High-dose remifentanil prevents development of thermal hyperalgesia in a neuropathic pain model N.A. Manering, T. Reuter, H. Ihmsen, D.C. Yeomans, A. Tzabazis British Journal of Anaesthesia Volume 110, Issue 2, Pages 287-292 (February 2013) DOI: 10.1093/bja/aes360 Copyright © 2013 The Author(s) Terms and Conditions

Fig 1 Behavioural testing after spinal nerve transection: (1a) Time course of mechanical allodynia (12 g von Frey filament) for the normal saline (saline), low-dose remifentanil (ld remi), and high-dose remifentanil (hd remi), respectively. (1b) Areas under the curve from 1a: no significant differences were found (two-way anova). (2a) Time course of cold allodynia (acetone test) for the normal saline (saline), low-dose remifentanil (ld remi), and high-dose remifentanil (hd remi), respectively. (2b) Areas under the curve from 2a: no significant differences were found (two-way anova). (3a) Time course of heat hyperalgesia (Hargreaves test) for the normal saline (saline), low-dose remifentanil (ld remi), and high-dose remifentanil (hd remi), respectively. (3b) Areas under the curve from 3a: rats that received intraoperative high-dose remifentanil exhibited significantly less heat hyperalgesia when compared with those that received normal saline and low-dose remifentanil, respectively. *P<0.05 in the post hoc Bonferroni comparison, two-way anova. pod, postoperative day; AUC, area under the curve. Data presented as mean (sem) (standard error of the mean). British Journal of Anaesthesia 2013 110, 287-292DOI: (10.1093/bja/aes360) Copyright © 2013 The Author(s) Terms and Conditions