Mechanical and cold hypersensitivity in nerve-injured C57BL/6J mice is not associated with fear-avoidance- and depression-related behaviour F.S. Hasnie,

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Mechanical and cold hypersensitivity in nerve-injured C57BL/6J mice is not associated with fear-avoidance- and depression-related behaviour F.S. Hasnie, V.C.J. Wallace, K. Hefner, A. Holmes, A.S.C. Rice British Journal of Anaesthesia Volume 98, Issue 6, Pages 816-822 (June 2007) DOI: 10.1093/bja/aem087 Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 1 Behavioural reflex sensitivity. Development of hypersensitivity to (i) punctate mechanical and (ii) cool stimuli in the ipsilateral hind paw of partial sciatic nerve ligated (PSNL) (n = 12 per group) vs sham-operated (n = 12 per group) mice on days (a) 6; (b) 13; and (c) 27 post-surgery. Statistical analysis was performed using the three-way anova followed by post-hoc tests where appropriate. *P < 0.05 or **P < 0.01 for ipsilateral response threshold compared with sham ipsilateral values. At all time points, PSNL injured animals developed significant sensitivity to both tests compared with sham-operated animals. British Journal of Anaesthesia 2007 98, 816-822DOI: (10.1093/bja/aem087) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 2 Open-field test. Outcome measures during a 15 min testing session were (a) percentage time spent in the inner zone (10 × 10 cm); (b) frequency of entry into inner zone; and (c) total distance travelled in the whole arena (40 × 40 cm). Data are shown for PSNL and sham-operated mice on days 7, 14, and 28 post-surgery. Statistical analysis was performed using the two-way anova followed by post-hoc tests where appropriate. *P < 0.05 compared with PSNL-operated animals on days 7 and 28 post-surgery; + P < 0.05 compared with sham-operated animals on days 7 and 28 post-surgery. British Journal of Anaesthesia 2007 98, 816-822DOI: (10.1093/bja/aem087) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 3 Elevated plus-maze test. Outcome measures during a 5 min testing session were: (a) (i) frequency of entry into the open arms and (ii) time spent in the open arms; (b) (i) frequency of entry into the closed arms and (ii) time spent in the closed arms; (c) (i) frequency of entry into the central square and (ii) time spent in the central square; and (d) total distance travelled in the maze. Statistical analysis was performed using the two-way anova followed by post-hoc tests where appropriate. #P < 0.05 compared with sham; **P < 0.05 compared with day 7 PSNL; and ++ P < 0.05 compared with day 7 sham. British Journal of Anaesthesia 2007 98, 816-822DOI: (10.1093/bja/aem087) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions

Fig 4 Tail suspension test. Immobility scores were measured on days 8, 15, and 29 post-surgery. No difference in immobility between PSNL and sham-operated animals was observed at any time point. There was significantly (P < 0.05) less immobility on day 29 than at earlier time points post-surgery. Statistical analysis was performed using the two-way anova followed by post-hoc tests where appropriate. *P < 0.05 compared with PSNL day 15; + P < 0.05 compared with sham day 15. British Journal of Anaesthesia 2007 98, 816-822DOI: (10.1093/bja/aem087) Copyright © 2007 British Journal of Anaesthesia Terms and Conditions