Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26 Susan.

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Genomewide Linkage Study in 1,176 Affected Sister Pair Families Identifies a Significant Susceptibility Locus for Endometriosis on Chromosome 10q26 Susan A. Treloar, Jacqueline Wicks, Dale R. Nyholt, Grant W. Montgomery, Melanie Bahlo, Vicki Smith, Gary Dawson, Ian J. Mackay, Daniel E. Weeks, Simon T. Bennett, Alisoun Carey, Kelly R. Ewen-White, David L. Duffy, Daniel T. O’Connor, David H. Barlow, Nicholas G. Martin, Stephen H. Kennedy The American Journal of Human Genetics Volume 77, Issue 3, Pages 365-376 (September 2005) DOI: 10.1086/432960 Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 1 Linkage (MLS) curves for all chromosomes in the combined data set, prior to inclusion of additional fine markers. This composite figure shows relative chromosome lengths. The genetic map of each chromosome is shown on the X-axis, and the MLS is shown on the Y-axis. Thresholds for significant (MLS=3.08) and suggestive (MLS=1.88) genomewide linkage are indicated by horizontal lines. The American Journal of Human Genetics 2005 77, 365-376DOI: (10.1086/432960) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 2 Fine mapping of chromosome 10 peak (A) and chromosome 20 peak (B). Linkage (MLS) curves are presented for the chromosomes before and after the addition of several markers, shown in different colors. Microsatellite markers are shown in genetic map order along the X-axis, with positions given in cM (Haldane). The Y-axis represents the MLS. The American Journal of Human Genetics 2005 77, 365-376DOI: (10.1086/432960) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 3 Study of origin strata at chromosome 10 peak (A) and chromosome 20 peak (B). Linkage (MLS) curves that include the fine markers are presented for the Australian and U.K. studies separately and also for the combined data set. Microsatellite markers are shown in genetic map order along the X-axis, with positions given in cM (Haldane). The Y-axis represents the MLS. A, Results show the increase in MLS when the two data sets are combined. The American Journal of Human Genetics 2005 77, 365-376DOI: (10.1086/432960) Copyright © 2005 The American Society of Human Genetics Terms and Conditions

Figure 4 Linkage in chromosome 10 conditional on linkage to chromosome 20. Chromosome 10 linkage curves are presented for families showing linkage at the chromosome 20 peak. Curves show MLS results for families linked to the chromosome 20 peak in the two studies separately and for all linked families. Microsatellite markers are shown in genetic map order along the X-axis, with positions given in cM (Haldane). The Y-axis represents the MLS. The American Journal of Human Genetics 2005 77, 365-376DOI: (10.1086/432960) Copyright © 2005 The American Society of Human Genetics Terms and Conditions