Tight junctions: Closing in on the seal

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Tight junctions: Closing in on the seal James Melvin Anderson, Christina M. Van Itallie Current Biology Volume 9, Issue 24, Pages R922-R924 (December 1999) DOI: 10.1016/S0960-9822(00)80105-0

Figure 1 Cross-section of a distal tubule from the rat kidney. (a) A diagram highlighting the distinction between the transcellular and paracellular pathways for movement of water and solutes across the tubule epithelium. The three photomicrographs show: (b) immunolocalization of occludin (green); (c) immunolocalization of claudin-1 (red); and (d) merged images, revealing the colocalization of both proteins (yellow) at the tight junctions, where they regulate paracellular transport. Nuclei are stained blue with DAPI in (d). Current Biology 1999 9, R922-R924DOI: (10.1016/S0960-9822(00)80105-0)